| Issue |
BIO Web Conf.
Volume 117, 2024
International Conference on Life Sciences and Technology (ICoLiST 2023)
|
|
|---|---|---|
| Article Number | 01049 | |
| Number of page(s) | 12 | |
| DOI | https://doi.org/10.1051/bioconf/202411701049 | |
| Published online | 05 July 2024 | |
Active Compound from An Indonesian Endophytic Fungus Talaromyces veruculosus BioMCC-f.EP.2165 Inhibiting Plasmodium falciparum Dihydroorotate Dehydrogenase as Antimalarial Agent
1 Research Center for Vaccine and Drug, National Agency for Research and Innovation (BRIN), Cibinong Science Center, Cibinong, West Java, Indonesia
2 Research Center for Applied Microbiology, National Agency for Research and Innovation (BRIN), Cibinong Science Center, Cibinong, West Java, Indonesia
3 Directorate of Scientific Collection Management, National Agency for Research and Innovation (BRIN), Cibinong, West Java, Indonesia
4 Department of Biomedical Chemistry, Graduate School of Medicine, The University of Tokyo, Tokyo 113-0033, Japan
* Corresponding author : nuki001@brin.go.id
An Indonesian endophytic fungus Talaromyces veruculosus BioMCC-f.EP.2165, was cultured to find compounds that showing inhibitory activity against Plasmodium falciparum dihydroorotate dehydrogenase (PfDHODH). Preliminary extraction test (PET) was conducted for examination of active compounds properties in fungal culture broth. Active compounds were extracted and purified based on a method derived from PET result. We isolated altenusin as an active compound from the fungal culture extract. Although, altenusin has been reported previously as an inhibitor of PfDHODH and inhibited the proliferation of Plasmodium falciparum 3D7, we isolated this compound from endophytic Talaromyces fungus for the first time.
© The Authors, published by EDP Sciences, 2024
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