Toxicological characteristics of a combined pyrethroid preparation

Federal Center for Toxicological, Radiation and Biological Safety, Department of Toxicology, Department of Virological and Ultrastructural Research, 420075 Kazan, Russia

^* Corresponding author: amil59@yandex.ru

Abstract

The article presents the toxicological characteristics of the combined drug Neostomosan, intended for the possibility of combating ectoparasites of farm animals in livestock buildings. It was found that the studied pyrethroid drug belongs to low-hazard agents. When administered intragastrically to laboratory mice, LD50 of Neostomosan was 11,500 mg/kg. When applied locally to the skin of animals, LD50 of the drug exceeded 10,000 mg/kg. The cumulation coefficient of Neostomosan was 10. A single treatment of calves with 0.3% of the drug did not cause toxicosis. After application of Neostomosan in this concentration, a reliable decrease in glucose levels on the 1st and 30th days, an increase in alanine aminotransferase activity on the 5th and 15th days, and a decrease in cholinesterase activity on the 15th day were noted in the blood of calves. The studied preparation did not cause any changes in the internal organs of the calves.