General toxicity study of a pyrethroid preparation with permethrin

Federal Center for Toxicological, Radiation and Biological Safety, Department of Toxicology, Department of Virological and Ultrastructural Research, 420075 Kazan, Russia

^* Corresponding author: amil59@yandex.ru

Abstract

This article presents the results of the general toxicity assessment of a pyrethroid preparation containing permethrin. The acute toxicity assessment of the preparation showed that the dose of 2060 mg/kg and 1545 mg/kg was the lowest dose that caused lethal outcome in rats and guinea pigs, respectively. A single administration of the studied preparation to rats and guinea pigs at doses of 1373 mg/kg and 1030 mg/kg 9, respectively, did not lead to death of the experimental animals. According to the OECD classification, the pyrethroid preparation with permethrin belongs to hazard class 4. Experiments on mice indicate that the studied preparation is not characterized by a cumulative effect. A single treatment of calves with a pyrethroid preparation containing permethrin at a concentration of 0.05% of the active substance did not cause signs of toxicosis, changes in the general condition and behavior of the animals. We also did not note any deaths of calves with a single treatment with the studied preparation at the above concentration. It was concluded that the pyrethroid preparation with permethrin does not have a toxic effect when used and can be classified as a safe drug.