The effect of Cd2+ ions on the passive permeability of the mitochondrial membrane of liver cell of Rats

¹ Samarkand State University named after Sharof Rashidov, Samarkand, Uzbekistan
² Research Institute of Biophysics and Biochemistry under the National University of Uzbekistan, Tashkent, Uzbekistan
³ Karshi State University, Karshi, Uzbekistan

^* Corresponding author: balikulov87@gmail.com

Abstract

This article describes the results of a study conducted on rats on the effects of heavy metal salts, including Cd²⁺ ions, on mitochondrial membranes. The experiments showed that heavy metals are one of the most dangerous sources of environmental pollution, and that they have a strong genotoxic, tumor-causing and cytotoxic effect when ingested. Cd²⁺ poisoning occurs in the metallurgical industry through inhalation of atmospheric air, consumption of contaminated food and water, and cigarette smoke. The studies showed that the studied heavy metal salts, Cd²⁺ ions, negatively affect the structure of the mitochondrial membrane, increasing the passive permeability of the membrane for monovalent H⁺, K⁺ and Na⁺ cations.