Issue |
BIO Web Conf.
Volume 135, 2024
4th International Conference on Pharmaceutical Updates (ICPU 2024)
|
|
---|---|---|
Article Number | 01003 | |
Number of page(s) | 5 | |
Section | Active Ingredients Discovery | |
DOI | https://doi.org/10.1051/bioconf/202413501003 | |
Published online | 07 November 2024 |
Isolation and Characterization of α-Cellulose From Beluntas Leaves (Pluchea Indica L.) Residue as Source of Microcrystalline Cellulose
Faculty of Pharmacy, Universitas Muhammadiyah Banjarmasin, Barito Kuala, Central of Borneo, Indonesia
Microcrystalline cellulose (MCC) is one of the pharmaceutical ingredients that is imported it is used as a binder in the manufacture of tablet drugs. The residue of Beluntas (Pluchea indica L) leaf extract is rarely used. This study aims to find out whether α-cellulose from beluntas leaf residue can be hydrolyzed into MCC and the characteristics of the MCC. α-cellulose was isolated using the Kraft method, then chemically hydrolyzed using 3.5 N HCl to obtain microcrystalline cellulose. Qualitative analysis of MCC includes organoleptic test, precipitation reaction using zinc chloride, and FTIR while physical evaluation includes pH and solubility. The α-cellulose obtained was 28.63 g from 150 g with a yield of 19.09%, while the MCC produced was 8.41 g (88.08%). Qualitative analysis of MCC from the residue of blunts leaf has shown similarity with the reference (Avicel PH 101). At the same time, the pH and solubility fulfilled the requirements of The United States Pharmacopoeia 2007. α-cellulose of Beluntas residue can be used for MCC preparation with the similar. Based on the qualitative analysis MCC from the residue of beluntas leaf has shown similar characteristics to reference (Avicel PH 101).
Key words: beluntas / hydrolysis / MCC
© The Authors, published by EDP Sciences, 2024
This is an Open Access article distributed under the terms of the Creative Commons Attribution License 4.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Current usage metrics show cumulative count of Article Views (full-text article views including HTML views, PDF and ePub downloads, according to the available data) and Abstracts Views on Vision4Press platform.
Data correspond to usage on the plateform after 2015. The current usage metrics is available 48-96 hours after online publication and is updated daily on week days.
Initial download of the metrics may take a while.