Role of Tribulus terrestris as an antioxidant against Oxidative Stress Induced by Sorafenib in adult male rats

Department of Biology, Faculty of Science, University of Kufa, Najaf, Iraq

^* Corresponding author: Shimaa.ahmed@uobabylon.edu.iq

Abstract

One of these therapeutic plants is Tribulus terrestris (Tt) therapeutic plants, or their secondary metabolites, have demonstrated a variety of biological benefits with widely varying pharmacological qualities. The purpose of this research was to evaluate the possible protective effects of Tribulus terrestris fruit aqueous extract against hepatotoxic effect of Sorafinib (Sor), an oral anti-cancer drug approved to treat renal cell carcinoma (RCC) that has progressed. Rats were split into four groups: interaction groups, Sorafinib alone treated group, Tribulus terrestris alone treated group, and normal control rats. The extract was administered at a dosage of 300 mg/kg body weight.600 mg/kg body weight was given orally by gavage for four weeks, and 60 mg/kg body weight was given orally by gavage for three weeks. The findings showed that, administration of Sorafinib caused a significant increase in Malondealdehyde (MDA) together with a significant decrease in GSH, GPX, CAT, SOD levels in comparison to negative control. Also significant decreases in MDA levels in Interaction groups and significant increase (P<0.05) in the rate of GSH, GPX,CAT,SOD levels compared to the positive group. On the other hand, Results showed that sorafenib theraby to male rats increased the activity of ALT, AST, and ALP. Tribulus treated rats were protected against Sorafenib induced liver damage by normalizing AST, ALT, and ALP levels. The present study showed therapeutic effect of Tribulus terrestris fruit aqueous extract on oxidative stress Sorafinib induced in hepatotoxicity in experimental rats.