Evaluating of aqueous and Alcoholic extracts of (Urtica pilulifera L.) in the hypersensitivity

Department of Biology, Faculty of Sciences, Kufa University, Najaf, Iraq

^* Corresponding author: aqbaly.alzeady@student.uokufa.edu.iq

Abstract

This study was devoted to the biological efficacy of the U.Pilulifera aqueous and Alcoholic extract at concentration of 100 mg/kg on hypersensitivity in adult Wiser albino rats induced by Bisphenol compound orally at a concentration of 1 mg/kg, for the period of experiment was 14 days. U.Pilulifera plants leafs were cleaned, the leaves were separated and dried, then well extracted with distilled water (D.W), a powder dissolved in distilled water and orally administered to the animals. Cytotoxicity of all plant extracts of U. Pilulifera used the human healthy blood hemolysis methods were show no hemolytic effect was recorded in all treatments with all extract concentration used. white laboratory rats weighing (168 –180 g) were used in this study were divided to 6 groups for each experiment, three replicates per group with a total of 18 rats for any experiment, and given oral treatment for a straight 14 days. The result showed that animals treated with Bisphenol had a significant (p <0.05) increase in IgE U/ml and Histamine U/ml content. From all the above results, the use of aqueous and Alcoholic extracts of U.Pilulifera plants may lead to the potential development of new treatments and a significant advance in pharmacology.