Issue |
BIO Web Conf.
Volume 142, 2024
2024 International Symposium on Agricultural Engineering and Biology (ISAEB 2024)
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Article Number | 03022 | |
Number of page(s) | 5 | |
Section | Microbial Engineering and Biomedical Exploration | |
DOI | https://doi.org/10.1051/bioconf/202414203022 | |
Published online | 21 November 2024 |
Advances in Research on Ubiquitin Modification and Deubiquitinating Enzymes in Cancer Therapy
School of Basic Medical Sciences, Nanjing Medical University, Nanjing 210000, China
* Corresponding author: 768431031@qq.com
Ubiquitination, as a classic protein post-translational modification, plays a key role in maintaining protein homeostasis. Protein ubiquitination is a constantly changing and reversible process. Deubiquitination refers to the specific removal of ubiquitin from substrate proteins, which, along with ubiquitin modification, collectively participate in the regulation of almost cellular functions within organisms. Irregularities in protein production, breakdown, and post-translational changes can contribute to the development of various diseases, such as cancer. The paper analyzed the mechanism and function of ubiquitination, including both polyubiquitination and monoubiquitination. The mechanism of deubiquitination was introduced as well. This review explores their implications in cancer, and the potential for targeting these processes in cancer therapy. Furthermore, the paper provides an overview of small molecule inhibitors (USP family) targeting deubiquitinating enzymes that could serve as drug targets in cancer. Finally, the recent research on the role of deubiquitinating enzymes in tumors was summarized, aiming to pave the way for precision medicine, new therapeutic targets in the diagnosis and treatment of cancer.
© The Authors, published by EDP Sciences, 2024
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