| Issue |
BIO Web Conf.
Volume 148, 2024
International Conference of Biological, Environment, Agriculture, and Food (ICoBEAF 2024)
|
|
|---|---|---|
| Article Number | 01006 | |
| Number of page(s) | 12 | |
| Section | Biological | |
| DOI | https://doi.org/10.1051/bioconf/202414801006 | |
| Published online | 09 January 2025 | |
Cardio and neuro protection by renin angiotensin aldosterone system-focus inhibition angiotensin converting enzyme: A systematic review
1 Faculty of Health, Universitas Muhammadiyah Magelang, Magelang, Central Java, Indonesia
2 Faculty of Pharmacy, Universitas Ahmad Dahlan, Yogyakarta, Daerah Istimewa Yogyakarta, Indonesia
* Corresponding author: akrom@pharm.uad.ac.id
One of the incidences of cardiovascular disease is stroke, which is a disease that occurs due to impaired brain function caused by damage to cerebral blood circulation. The presence of risk factors for hyperglycemia or hypertension can result in endothelial nitric oxide (eNOS) dysfunction, thereby causing oxidative stress and vasoconstriction of blood vessels. The renin angiotensin system is involved in the physiopathology of stroke and has an important impact on hypertension. This article targets the role of the renin angiotensin system specifically the inhibition of the angiotensin converting system in cardioprotection and neuroprotection. The mechanism of action of the renin-angiotensin-aldosterone system (RAAS) is observed through effects on AT1, AT2 and Mass receptors. The future relationship of cardiovascular disease and the renin-angiotensin system is full of possibilities, as new agonist molecules emerge as potential candidates to limit the impairments caused by cardiovascular disease.
© The Authors, published by EDP Sciences, 2024
This is an Open Access article distributed under the terms of the Creative Commons Attribution License 4.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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