| Issue |
BIO Web Conf.
Volume 148, 2024
International Conference of Biological, Environment, Agriculture, and Food (ICoBEAF 2024)
|
|
|---|---|---|
| Article Number | 04005 | |
| Number of page(s) | 20 | |
| Section | Food | |
| DOI | https://doi.org/10.1051/bioconf/202414804005 | |
| Published online | 09 January 2025 | |
Nanoparticles-mediated delivery of herbal extract: Impact on inhibition advanced glycation end-product (AGEs): A systematic review
1 Study Program of Pharmacy, Politeknik Kesehatan TNI AU Adisutjipto, Bantul, Daerah Istimewa Yogyakarta, Indonesia
2 Faculty of Pharmacy, Universitas Ahmad Dahlan, Yogyakarta, Daerah Istimewa Yogyakarta, Indonesia
3 Faculty of Pharmacy, Universitas Gadjah Mada, Yogyakarta, Daerah Istimewa Yogyakarta, Indonesia
* Corresponding author: febrianafarmasis@gmail.com
This systematic review compiles and analyzes research on the therapeutic efficacy of nanoparticle-mediated delivery systems for herbal extracts aimed at inhibiting the formation of Advanced Glycation End- products. A comprehensive search of PubMed and Google Scholar was conducted in accordance with the PRISMA systematic review statement guidelines included studies published within the past 10 years. Our examination spans several studies utilizing different nanoparticle formulations—such as gold, silver, and zinc oxide nanoparticles—and encapsulated herbal extracts, including Poria cocos, Nigella sativa, and curcumin, among others. The outcomes indicate that these nanocomplexes not only foster enhanced delivery and bioavailability of the herbal extracts but also significantly decrease inflammatory biomarkers and blood glucose levels, enhance antioxidant responses, and protect against cellular damage caused by oxidative stress. This review emphasizes the potential of nanoparticles to augment the therapeutic properties of herbal medicines for preventing and managing diabetic complications through the inhibition of AGEs formation.
© The Authors, published by EDP Sciences, 2024
This is an Open Access article distributed under the terms of the Creative Commons Attribution License 4.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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