Justification of the component composition of the drug “DB” for dry hoof baths

Federal Center for Toxicological, Radiation and Biological Safety, Laboratory of Cell Cultures and Nutrient Media, 420075 Kazan, Russia

^* Corresponding author: evgenechka1885@gmail.com

Abstract

This paper presents the results of substantiation of the component composition of the medicinal product «DB» for dry hoof baths for the treatment and prevention of infectious and non-infectious diseases of the distal extremities of cattle. The selection of the most optimal composition was carried out based on the results of studying the adsorption activity of 13 experimental samples and determining the minimum bactericidal (fungicidal) concentration of 10 experimental samples. The maximum adsorption and antimicrobial activity of the sample, which includes bentonite, copper sulfate, zinc sulfate, polyvinyl alcohol, perlite, camphor oil and sodium benzenesulfochloramide (called «DB») is shown. The tests showed that the composition of «DB» is the most optimal combination of the substances used, which complemented each other, leading to increased adsorption, bactericidal and anti-inflammatory properties. The developed means for dry hoof baths installed in places where animals are driven will be most effective in the initial (maceration, microtrauma, fresh wounds, etc.) and middle stages of infectious diseases of the distal extremities, which will significantly reduce the incidence and development of severe infectious forms of diseases. In this regard, the introduction of this means into the technology of cattle breeding will reduce labor costs for the prevention and treatment of cattle, will contribute to an increase in the period of economic use of animals, a decrease in the development of antibiotic resistance of pathogenic microorganisms and an increase in the profitability of cattle breeding as a whole.