| Issue |
BIO Web Conf.
Volume 149, 2024
International Scientific and Practical Conference on Genetic Resources (Genetic Resources 2024)
|
|
|---|---|---|
| Article Number | 01050 | |
| Number of page(s) | 5 | |
| DOI | https://doi.org/10.1051/bioconf/202414901050 | |
| Published online | 28 November 2024 | |
Hypomethylation of the p53 and p16 suppressor genes in cellular aging
1 Institute of Biophysics And Biochemistry at the National University of Uzbekistan Named after M.Ulugbek in Tashkent, Uzbekistan
2 Tashkent State Pedagogical University named after Nizami, Tashkent, Uzbekistan
3 Tashkent State Agrarian University, Tashkent, Uzbekistan
* Corresponding author: d.kadyrova1949@mail.ru
Protein p53, a product of p53 gene expression, protects the integrity of the genome throughout life and promotes the cell repair in the process of cell aging. In this review, the fundamental significance of the p53 gene was analyzed in the cell aging. The review showed that hypomethylation of the promoter region of the p53 and p16 suppressor genes occurs during aging; the DNA hypomethylation is explained by the possible age-related decrease in the content of CH3-groups donor (S-adenosyl monophosphate) in the cell, and by the activity of DNA methyltransferases.
© The Authors, published by EDP Sciences, 2024
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