Issue |
BIO Web Conf.
Volume 154, 2025
15th International Conference on Global Resource Conservation (ICGRC 2024) in conjunction with the 1st International Conference on Jamu and Alternative Medicine (ICJAM 2024)
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Article Number | 02002 | |
Number of page(s) | 13 | |
Section | Biotechnology and Bioprospecting | |
DOI | https://doi.org/10.1051/bioconf/202515402002 | |
Published online | 28 January 2025 |
In vitro studies on the immunomodulatory effects of fulvic acid extract from palm oil empty fruit bunch (OPEFB)
1 Indonesian Oil Palm Research Institute, Bogor, Indonesia
2 Primate Research Center, Bogor Agricultural University, Bogor, Indonesia
* Corresponding author: firda.dimawarnita@gmail.com
This study evaluates the potential of Fulvic Acid (FA), derived from oil palm empty fruit bunches (OPEFB), as an immunomodulatory agent through in vitro analysis. Fulvic Acid, a component of humic substances, is known for its wide-ranging applications in agriculture, biotechnology, and medicine. With an increasing need for sustainable natural therapies, FA has shown promise in treating degenerative diseases by modulating immune responses. The research focused on assessing the immunomodulatory effects of FA by analysing its impact on cytokine production. In vitro studies used the MTT assay to determine cytotoxicity and ELISA tests to measure cytokines associated with natural immunity (TNF-alpha and Interferon-gamma) and adaptive immunity (IL-2 and TGF-beta). Comparative evaluations were performed using FA samples from Shilajit and a fertiliser product. Results demonstrated that FA derived from OPEFB significantly enhanced cytokine production, suggesting its potential as an immunomodulatory agent. These findings indicate that FA from OPEFB could be a promising candidate for developing treatments for degenerative diseases. Further studies are recommended to explore its therapeutic potential and commercial application in the health sector.
© The Authors, published by EDP Sciences, 2025
This is an Open Access article distributed under the terms of the Creative Commons Attribution License 4.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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