Issue |
BIO Web Conf.
Volume 154, 2025
15th International Conference on Global Resource Conservation (ICGRC 2024) in conjunction with the 1st International Conference on Jamu and Alternative Medicine (ICJAM 2024)
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Article Number | 02008 | |
Number of page(s) | 23 | |
Section | Biotechnology and Bioprospecting | |
DOI | https://doi.org/10.1051/bioconf/202515402008 | |
Published online | 28 January 2025 |
Integrated bioinformatic approach of Balur therapy for breast cancer subtypes
1 Lembaga Penelitian Peluruhan Radikal Bebas, Malang, Indonesia
2 Department of Biology, Faculty of Mathematics and Natural Sciences, Universitas Brawijaya, Malang, Indonesia
* Corresponding author: sutiman@ub.ac.id
Balur is a topical complementary alternative medicine that can be applied to breast cancer. Balur eliminates free radicals and heavy metals which it found enhance in cancer patients compared with healthy persons. Balur uses materials that potentially can halt cancer progression and development such as aspirin, coffee, moringa, and tobacco. This study was to describe the complexity of Balur in the biological system of breast cancer subtypes such as luminal A, liminal B, and HER-2, which had been found in high numbers in Indonesia, with an integrative bioinformatic approach. Active compounds found from literature studies were collected and screened by skin permeability variables. For breast cancer subtypes, differential expressed gene (DEG) identification was used to explore the target of Balur compounds. The Cytoscape software was used to construct the network of Balur compounds and target proteins of breast cancer subtypes. Gene Ontology, pathway, docking, hub gene, and survival analysis were applied to investigate the detailed mechanism of Balur to breast cancer in each subtype. The results showed that Balur compounds targeted respectively 68, 86, and 84 genes of luminal A, luminal B, and HER-2. From these target genes, 7 Balur compounds had higher binding energy than chemotherapy compounds when they docked with hub genes from each subtype. In conclusion, this study explained the pharmacological mechanisms of Balur therapy, which has great potential as a complementary therapy for breast cancer subtypes.
© The Authors, published by EDP Sciences, 2025
This is an Open Access article distributed under the terms of the Creative Commons Attribution License 4.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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