| Issue |
BIO Web Conf.
Volume 166, 2025
2025 International Conference on Biomedical Engineering and Medical Devices (ICBEMD 2025)
|
|
|---|---|---|
| Article Number | 01003 | |
| Number of page(s) | 4 | |
| Section | Neuroscience and Frontier Technology in Medicine | |
| DOI | https://doi.org/10.1051/bioconf/202516601003 | |
| Published online | 10 March 2025 | |
The link between microglia and adult hippocampal neurogenesis provides a new target for the intervention and treatment of neurodegenerative diseases
Life Science, Tongji University, Shanghai 200092, China
Adult hippocampal neurogenesis (AHN) is closely related to hippocampal plasticity, learning, memory and post-injury repair of the brain. In patients with neurodegenerative diseases, the ability of neural stem cells to proliferate and generate new neurons is sharply decreased, and AHN level is significantly weakened, which is not conducive to the repair of brain function. As immune cells in the nervous system, microglia play an important role in the generation and integration of new neurons. There is evidence that microglia are critical to the regulation of adult hippocampal neurogenesis, and different groups of microglia can perform different functions. Therefore, the link between microglia and adult hippocampal neurogenesis provides a new target for intervention in neurodegenerative diseases. This paper summarizes the modulating effect of microglia on adult hippocampal nerve and provides new ideas for solving the problems related to neurodegenerative diseases.
© The Authors, published by EDP Sciences, 2025
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