| Issue |
BIO Web Conf.
Volume 166, 2025
2025 International Conference on Biomedical Engineering and Medical Devices (ICBEMD 2025)
|
|
|---|---|---|
| Article Number | 01004 | |
| Number of page(s) | 4 | |
| Section | Neuroscience and Frontier Technology in Medicine | |
| DOI | https://doi.org/10.1051/bioconf/202516601004 | |
| Published online | 10 March 2025 | |
Microglia mediated by SuM-ABN axis restores cognitive dysfunction and postones AD progression
Department of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nangjing 211100, China
Microglia, a kind of highly dynamic central neural system immunity cells, transform phenotype based on diverse stimuli, playing vital roles in adult neurogenesis and synaptic connection for affecting AD progression. Particularly, microglia are mainly composed of anti-inflammatory types in mild AD patients, which offer immune surveillance to clear away amyloid beta plaques and facilitate adult neurogenesis. However, these microglia transform into pro-inflammatory alike phenotype to accelerate the deterioration of the disease if exposed to chronic but slow-level plaques stimulation. Thus, how to control microgial prototype becomes a promising therapeutic direction. It has been found that adult-born neurons activation mediated by SuM stimulation in early AD mice could promote microglia phagocytosis, improving cognitive functions. In this paper, I focus on whether microglia promote AHN by increasing BDNF release after SuM-ABN activation and whether chronic ABN-stimulated microglia could transform or maintain anti-inflammatory phenotype to prevent improper synaptic cut, leading to cognitive enhancement.
© The Authors, published by EDP Sciences, 2025
This is an Open Access article distributed under the terms of the Creative Commons Attribution License 4.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Current usage metrics show cumulative count of Article Views (full-text article views including HTML views, PDF and ePub downloads, according to the available data) and Abstracts Views on Vision4Press platform.
Data correspond to usage on the plateform after 2015. The current usage metrics is available 48-96 hours after online publication and is updated daily on week days.
Initial download of the metrics may take a while.