| Issue |
BIO Web Conf.
Volume 166, 2025
2025 International Conference on Biomedical Engineering and Medical Devices (ICBEMD 2025)
|
|
|---|---|---|
| Article Number | 01006 | |
| Number of page(s) | 5 | |
| Section | Neuroscience and Frontier Technology in Medicine | |
| DOI | https://doi.org/10.1051/bioconf/202516601006 | |
| Published online | 10 March 2025 | |
Molecular Pathways of Neuronal Apoptosis in Neurodegenerative Diseases and Intervention Strategies
Hong Kong University of Science and Technology, Hong Kong, China
* Email: 3800679351@qq.com
Neurodegenerative diseases are a group of progressive conditions characterized by the dysfunction and death of neurons, leading to cognitive and motor impairments. A key process in the pathogenesis of these diseases is neuronal apoptosis, which is regulated by a complex array of molecular pathways. This paper provides an overview of the intrinsic and extrinsic apoptotic pathways, highlighting the critical role of caspases in executing cell death. It also discusses additional pathways, such as endoplasmic reticulum stress, DNA damage response, and autophagy, which contribute to the initiation and progression of neuronal apoptosis in neurodegenerative diseases.
© The Authors, published by EDP Sciences, 2025
This is an Open Access article distributed under the terms of the Creative Commons Attribution License 4.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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