The Rapid Detection of Cardiac Myocyte Damage Markers and Their Clinical Significance in Acute Cardiovascular Events

¹ BASIS International School Guangzhou, Guangzhou, China
² Agricultural University of Hebei, Baoding, China

^* memooffers@outlook.com

Abstract

Background: Acute cardiovascular events (ACEs) are a leading cause of mortality worldwide, and the rapid identification and detection of myocardial injury markers are critical for improving patient outcomes. This study evaluated the prognostic value of key myocardial injury biomarkers—troponin, creatine kinase-MB (CK-MB), and B-type natriuretic peptide (BNP)—in predicting adverse outcomes in ACEs.

Methods: A retrospective cohort study design was employed, including patients with acute cardiovascular events to analyze the association between levels of myocardial injury markers (troponin, CK-MB, BNP) during hospitalization and adverse outcomes, including mortality and rehospitalization rates. Statistical methods such as chi-square tests, Kaplan-Meier survival curves, ROC curves, and Cox proportional hazards models were used to assess the predictive power of these biomarkers for adverse outcomes.

Results: The analysis showed a significant association between elevated levels of troponin, CK-MB, and BNP with adverse prognoses. Elevated troponin levels, in particular, were strongly predictive of mortality and rehospitalization rates, with an AUC of 0.84, demonstrating high diagnostic accuracy. Additionally, CK-MB and BNP levels were significant predictors of adverse cardiovascular events, highlighting their clinical relevance.

Conclusion: The findings indicate that rapid detection of myocardial injury biomarkers holds substantial value in diagnosing and prognosticating acute cardiovascular events. Monitoring levels of troponin, CK-MB, and BNP can provide valuable support for clinical decision-making, contributing to improved patient management and outcomes in emergency settings.