Synthesis and antibacterial activity of benzimidazole amides based on computer-aided technology

Chongqing Chemical Industry Vocational College, Chongqing, China

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Abstract

Benzimidazole compounds are benzoheterocyclic compounds containing 2 nitrogen atoms. These compounds not only have broad-spectrum biological activities such as antihypertensive, antiparasitic, antibacterial and antifungal, but also play a great role in pharmacological activity and metal ligands. Therefore, the study of benzimidazole compounds has become one of the hot spots in recent years, especially in the field of medicinal chemistry. Benzimidazolamide compounds were synthesized from 2-mercaptobenzimidazole, 2-chloroacetamide, benzyl chloride, 2, 4-dichlorobenzyl chloride and 3-chlorobenzyl chloride by S-alkylation and n-alkylation reactions. The structure of the new compounds was determined by IR, MS and other modern analytical methods, and the antimicrobial activity was studied. And the basic methods of computer-aided drug design are introduced. This study has improved the heterocycles of such compounds, which will certainly be easier and more conducive to understanding its special function and drug activity mechanism, so as to provide a good research basis for the development of antimicrobials.