Issue |
BIO Web Conf.
Volume 109, 2024
Conference on Water, Agriculture, Environment and Energy (WA2EN2023)
|
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Article Number | 01019 | |
Number of page(s) | 11 | |
DOI | https://doi.org/10.1051/bioconf/202410901019 | |
Published online | 20 May 2024 |
Antimicrobial activity and molecular docking studies of some imidazo[2,1-b]thiazole derivatives
1 Laboratory of Applied Chemistry and Environments (LCAE), Faculty of Sciences, University Mohammed Premier, Oujda, Morocco
2 Laboratory of Molecular Chemistry, Materials and Environments, Polydisciplinary Faculty of Nador, UMP, Morocco
3 Laboratory of Physiology, Genetics and Ethnopharmacology Faculty of Sciences Oujda, UMP, Morocco
4 Environmental Technologies, Biotechnology and Valorization of Bio-Resources Team, Faculty of Sciences and Techniques of Al-Hoceima, Abdelmalek Essaadi University, Tetouan, Morocco
The synthesis of bioactive molecules is of major importance in the pharmaceutical industry. In this context, the study was conducted to determine the antimicrobial and antifungal potential of four chalcone-based imidazo[2,1-b]thiazole derivatives already synthesized by our research group. The synthetized compounds obtained in good yield were evaluated for their antibacterial and antifungal activities against E. coli, Staphylococcus aureus, Pseudomonas aeruginosa and Fusarium, the results obtained are compared with the standard. Molecular docking studies were utilized to forecast the potential of these molecules as antimicrobial agents, the results obtained in vitro antibacterial were well confirmed by this method.
Key words: Imidazothiazole / Antibacterial / Antifungal / Molecular Docking
© The Authors, published by EDP Sciences, 2024
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