The Efficacy of Pattern Separation Training in Antidepressant Treatment and the Exploration of Its Drug-Target Alternatives

Department of Marine Science, Sun Yat-Sen University, Zhuhai 519000, China

^* liuj398@mail2.sysu.edu.cn

Abstract

Current treatments for MDD focus on pharmacological treatments, psychotherapeutic interventions, and somatic treatments. The core goal of this study is to develop an innovative non-pharmacological treatment method, which produces antidepressant effects similar to those of antidepressant drugs, mainly through pattern separation training in cognitive training, which has the advantages of being non-invasive, having fewer side-effects, and reducing relapse. At the same time, we use the transcriptome to detect changes in molecular mechanisms brought about by pattern separation training, find differentially expressed genes, and probe deeply into the molecular mechanisms behind them in order to find potential drug targets. Through this approach, we hope to provide more diverse treatment options for patients with depression, while reducing dependence on drug therapy.