| Issue |
BIO Web Conf.
Volume 174, 2025
2025 7th International Conference on Biotechnology and Biomedicine (ICBB 2025)
|
|
|---|---|---|
| Article Number | 02021 | |
| Number of page(s) | 7 | |
| Section | Innovations in Therapeutics and Disease Mechanisms | |
| DOI | https://doi.org/10.1051/bioconf/202517402021 | |
| Published online | 12 May 2025 | |
SLC7A5: A Potential Molecular Target for the Diagnosis and Treatment of TNBC
1 Medical College, Wuhan University of Science and Technology, Wuhan 430065, Hubei, China
2 College of Life Sciences and Health, Wuhan University of Science and Technology, Wuhan 430065, Hubei, China
3 TianJin KingYork Group Hubei TianYao Pharmaceutical Co., Ltd, Xiangyang 441004, Hubei, P.R. China
* Corresponding author: a xiongjing@wust.edu.cn and b xinghualiao@wust.edu.cn
c wangjincheng8848@163.com; d qq1216248031@163.com
e 15272556211@163.com; f carolin_cui@163.com g liuyimeng@wust.edu.cn; h jiangshu@wust.edu.cn i guohongshan@wust.edu.cn
TNBC is a highly heterogeneous malignant tumor with limited clinical treatment options and efficacy. Through a series of analyses and screenings, we have identified SLC7A5 as a potential biomarker for targeted therapy of TNBC. Experimental results have shown that knocking down SLC7A5 can significantly inhibit the proliferation of TNBC, and we have also identified quercetin, a Chinese herbal ingredient with lower cost and efficacy comparable to the existing SLC7A5 specific inhibitor JPH-203. Experimental results have shown that quercetin can also significantly inhibit the proliferation of TNBC. Our research provides new ideas and lessons for clinical treatment.
© The Authors, published by EDP Sciences, 2025
This is an Open Access article distributed under the terms of the Creative Commons Attribution License 4.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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