Issue |
BIO Web Conf.
Volume 153, 2025
The 3rd IPB International Conference on Nutrition and Food (ICNF 2024)
|
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Article Number | 01006 | |
Number of page(s) | 10 | |
Section | Clinical Nutrition | |
DOI | https://doi.org/10.1051/bioconf/202515301006 | |
Published online | 28 January 2025 |
The potential of Dayak tribal herbal leaves as an anti-breast cancer agent: In silico approach
1 Biology Education Study Program, Faculty of Teacher Training and Education, Mulawarman University, 75119 Samarinda, Indonesia
2 Generasi Biologi Indonesia Foundation, 61171 Gresik, Indonesia
3 Department of Biology, Faculty of Science and Technology, Universitas Airlangga, 60115 Surabaya, Indonesia
4 Division of Research and Development, CV Jalan Tengah, Pasuruan, Indonesia
5 Postgraduate School, Universitas Airlangga, 60115 Surabaya, Indonesia
6 Uttaranchal Institute of Pharmaceutical Sciences, Uttaranchal University, Dehradun, India
7 Research Center of Natural Products from Tropical Rainforest (PUI-PT OKTAL), Mulawarman University, Indonesia
* Corresponding author: doraturistaofficial@gmail.com
Breast cancer is one of the leading causes of mortality among women worldwide, prompting the exploration of alternative, natural therapies. This study examines the anti-breast cancer potential of traditional herbal plants used by the Dayak tribe, particularly Kleinhovia hospita Linn. Through in silico approaches, the study investigates the cytotoxic effects and binding affinities of key compounds, such as Scopoletin, Quercetin, and Eleutherol, with breast cancer-related proteins. Molecular docking analysis demonstrated that Quercetin and Eleutherol exhibit high binding affinities (−9 and −8 kcal/mol, respectively) with target proteins, indicating significant potential for inhibiting cancer cell proliferation by targeting proteins like EGFR, JNK, and NUDT5. The drug-likeness analysis confirmed that Quercetin and Eleutherol meet criteria for further therapeutic exploration. These findings suggest that compounds from Dayak tribal plants could be viable anti-cancer agents, providing a scientific foundation for developing culturally relevant and effective treatments for breast cancer. Further research is recommended to isolate and evaluate the bioactive compounds in preclinical and clinical settings. This work supports the potential of traditional Dayak herbal medicine as a natural therapeutic strategy against breast cancer.
© The Authors, published by EDP Sciences, 2025
This is an Open Access article distributed under the terms of the Creative Commons Attribution License 4.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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