Issue |
BIO Web Conf.
Volume 183, 2025
International Conference on Life Sciences and Technology (ICoLiST 2024)
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Article Number | 01001 | |
Number of page(s) | 12 | |
DOI | https://doi.org/10.1051/bioconf/202518301001 | |
Published online | 09 July 2025 |
Effect of Moringa oleifera Seed Oil on IL-Iβ and IL-18 Gene Expression in Mice (Mus muculus) Liver Fibrosis Model
1 Departement of Biology, Faculty of Mathematics and Natural Sciences, Universitas Negeri Malang, Semarang St. 5, Malang 65145, Indonesia
2 Departement of Biosciences, Faculty of Sciences, Universiti Teknologi Malaysia, Iman St., 81310 Skudai, Johor Darul Ta’zim, Malaysia
* Corresponding author: hendrabio@um.ac.id
Liver fibrosis is a common pathological condition that can progress to cirrhosis and hepatocellular carcinoma. One potential treatment involves natural ingredients, such as moringa seed oil (MOSEIL). The proinflammatory cytokines IL-1β and IL-18 play a role in liver fibrosis pathogenesis, and their increased expression may indicate fibrosis progression. This study examines the effect of MOSEIL on IL-1β and IL-18 gene expression in a liver fibrosis mouse model induced by CCl4 BALB/c mice were treated with CCl4 for one month, followed by CCl4 and MOSEIL in the second month. Gene expression was analyzed using RT-qPCR. The results showed that MOSEIL prevented weight loss in mice and altered liver morphology, including color changes, lump formation, and cell infiltration in histopathology. Additionally, MOSEIL suppressed IL-1β and IL-18 expression, inhibiting fibrosis progression. In conclusion, MOSEIL can reduce fibrosis development by modulating pro-inflammatory gene expression. These findings support its potential use in developing MOSEIL-based treatments for chronic liver disease.
© The Authors, published by EDP Sciences, 2025
This is an Open Access article distributed under the terms of the Creative Commons Attribution License 4.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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