| Issue |
BIO Web Conf.
Volume 41, 2021
The 4th International Conference on Bioinformatics, Biotechnology, and Biomedical Engineering (BioMIC 2021)
|
|
|---|---|---|
| Article Number | 07007 | |
| Number of page(s) | 6 | |
| Section | Drug Development and Nutraceutical | |
| DOI | https://doi.org/10.1051/bioconf/20214107007 | |
| Published online | 22 December 2021 | |
Animal Models of Alcoholic Liver Disease for Hepatoprotective Activity Evaluation
1
Master of Pharmaceutical Science Program, Faculty of Pharmacy, Universitas Gadjah Mada, Yogyakarta 55281, Indonesia
2
Department of Pharmaceutical Biology, Faculty of Pharmacy, Universitas Gadjah Mada, Yogyakarta, 55281, Indonesia
3
Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, Universitas Gadjah Mada, Yogyakarta, 55281, Indonesia
* Corresponding author: retno_murwanti@ugm.ac.id
Background: The reported statistics suggest that alcoholic liver disease is on the rise. Furthermore, medications used to treat the disease have unpleasant effects, and this necessitates the need to continuously investigate hepatoprotective agents. This study investigates animal models of alcoholic liver disease used to evaluate hepatoprotective activity. Content: A good number of published articles evaluating hepatoprotective activity were summarized. The studies used three ethanol-induced liver injury models: the acute ethanol-induced liver injury model, the chronic ethanol-induced liver injury model, and Lieber– DeCarli model. Summary: Wistar rats were primarily used in the ethanol-induced liver injury model. High levels of alanine transaminase (ALT) and aspartate transaminase (AST) and histopathological alterations were found in all animal models (acute ethanol-induced liver injury, chronic ethanol-induced liver injury, and Lieber–DeCarli models). Severe steatosis was shown in both chronic ethanol-induced liver injury and Lieber–DeCarli models. However, fibrosis was undetected in all models.
Key words: Alcoholic liver disease / animal models / hepatoprotective activity / liver injury / ethanol
© The Authors, published by EDP Sciences, 2021
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