The Effect of Alcohol Drink Consumption on Mice (Mus muculus) Liver Damage

Department of Medical Laboratory Technology, Faculty of Health, Universitas Nahdlatul Ulama Surabaya, Jawa Timur, Indonesia

^* Corresponding author: ersalinanidianti@unusa.ac.id, aryandini@unusa.ac.id, mutiaraalfiansyah061.nk20@student.unusa.ac.id, m.afwanromdloni@unusa.ac.id

Abstract

Consuming alcoholic beverages can cause someone to become addicted to alcohol, because alcoholic beverages are addictive substances that have a negative impact on health if consumed regularly. Excessive consumption of alcoholic beverages can cause liver damage, heart damage, stroke, high blood pressure, digestive tract cancer, memory loss and confusion. This study aims to determine the effect of alcoholic beverages on liver damage in mice. Methods: The Type of research is experimental with a post-test only control group design. This study used 30 mice divided into 6 groups. Group 1 as a negative control (non treatment), group 2 as a positive control (70% ethanol), group 3 as a standard (CCl4), group 4 was given 0.3 ml of alcohol drink code 1 treatment, group 5 was given 0.5 ml of alcohol drink code 1 treatment, and group 6 was given 0.7 ml of alcohol drink code 1 treatment orally for 14 days. The 15th day continued with surgery and blood sampling through the heart, then AST and ALT levels were measured. Results: The average AST results per group, in the negative control group were 78.52 U/L, the positive control group were 98.73 U/L, the standard group were 107.75 U/L, treatment group 1 were 80.21 U/L, treatment group 2 were 89.54 U/L, and treatment group 3 were 109.84 U/L. While the average ALT per group, in the negative control group were 88.66 U/L, the positive control group were 115.18 U/L, the standard group were 116.56 U/L, treatment group 1 were 91.41 U/L, treatment group 2 were 101.4 U/L and treatment group 3 were 130.2 U/L. Conclusion: There was no significant effect of consuming alcoholic beverages on liver damage as measured by AST and ALT levels.