Issue |
BIO Web Conf.
Volume 183, 2025
International Conference on Life Sciences and Technology (ICoLiST 2024)
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Article Number | 01025 | |
Number of page(s) | 10 | |
DOI | https://doi.org/10.1051/bioconf/202518301025 | |
Published online | 09 July 2025 |
Antibacterial Efficacy of Zinc and Zirconium Based Metal Organic Frameworks against Escherichia coli and Staphylococcus aureus
1 Biology Education, Faculty of Mathematics and Sciences, State University of Malang, Malang, Indonesia
2 Physical Education, Faculty of Mathematics and Sciences, State University of Malang, Malang, Indonesia
3 SMA Laboratorium UM, Malang, Indonesia
* Corresponding author: nanapujiono@gmail.com
Bacterial resistance to antibiotics, affecting both Gram-positive and Gram-negative bacteria, remains a major challenge. Zn-MOF and Zr-MOF offer promising antibacterial properties through metal ion release and membrane disruption. In this research, Zn-MOF and Zr-MOF were synthesized using the solvothermal method and antibacterial tests were carried out. The solids formed were then characterized using ATR-FTIR, XRD and SEM. The results of analysis using ATR-FTIR show that the Zn-MOF functional groups appear at wavelengths 3666-3036 cm-1(vO-H), 1587 cm-1 (v-OCO-sym), 1392 cm-1 (v-OCO-asym), 837 cm-1 (vC-H), 748cm-1 (vC=C) and 651cm-1(vZn-O) while the Zr-MOF functional group appears at a wavelength of 3658-3174 cm-1 (vO-H), 1562cm-1 (v-OCO-sym), 1390cm-1 (v-OCO-asym), 823cm-1 (vC-H), 742cm-1 (vC=C) and 563cm-1 (vZr-O). The results of XRD analysis show that the characteristic peak of Zn-MOF is at 20 6.8°; 9.6°; 13.72°; 15.44°; 20.6° while the distinctive peak of Zr-MOF is shown at 20 7.32°; 8.48°; 11.9°; 14.0°; 14.6°; and 17.0°. Meanwhile, SEM results show that Zn-MOF has a cubic surface structure while Zr-MOF has aggregated particles with an irregular round shape. The results of the antibacterial test for Staphylococcus aureus showed that Zn-MOF (38.9 ± 1 mm) had a largest zone of inhibition, equivalent to the results of the antibacterial test for Escherichia coli showing that Zn-MOF (36.2±1 mm) has a largest zone of inhibition.
© The Authors, published by EDP Sciences, 2025
This is an Open Access article distributed under the terms of the Creative Commons Attribution License 4.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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