Synthesis of a 17-Beta Estradiol Nano-Formulation as a Promising Wound Healing Agent

¹ Department of Zoology, Government Victoria College, Palakkad, Kerala, India
² Department of Zoology, University of Calicut, Malappuram - 673635, Kerala, India

^* Corresponding author: lachusuresh2017@gmail.com

Abstract

This is the first report of an estradiol reduced silver nanoparticle synthesis and characterization. Estrogen has a significant role on wound regeneration. 17-beta Estradiol, being a highly mitotic wound regenerative compound with reported wound healing activity is widely used as cutaneous applicant and as gels in degenerate wounds. Estrogen (E2) is involved in regulating inflammation, re-epithelialization, vascular organization, collagen deposition, fibroblast and keratinocyte migration in wounds. Even though the topical application of Estradiol is of high regeneration value the complications of systemic absorption limits their utility as an external applicant. The study concentrate to develop a noval combination of Estradiol and nano silver , a promising wound regenerative nano drug formulation-17β-Estradiol-reduced silver nanoparticle (ESNP) which may release the hormone slowly in very low concentrations on wounds, simultaneously, protecting the wound from microbial attack and biofilm formation due to the action of nano-silver. ESNP synthesis has been optimized and characterized by UV-VIS spectroscopy, TEM, SEM, DLS, XRD and FT-IR. Previous reports on other Estradiol Nano formulation has been exhibiting an induced neuronal regeneration in Spinal Cord Injury models (SCI), further experimentation of the drug may reveal its potential as a topical wound regenerative drug.