Antiviral Potential of Polysaccharides Extracted from Marine Macroalgae of the El Jadida Atlantic Coast (Morocco)

¹ Laboratory of Marine Biotechnologies and Environment – CNRST Labeled Research Unit, Faculty of sciences, Chouaib Doukkali University, BP 20, El Jadida 24000, Morocco
² Laboratory of Physical Chemistry of Materials, Department of Chemistry, University Chouaïb Doukkali, P.O. Box 20, El Jadida, 24000, Morocco
³ Laboratoire de Biotechnologie et Chimie Marines, Universit´e Bretagne Sud, Lorient, France

^* Corresponding author: This email address is being protected from spambots. You need JavaScript enabled to view it.

Abstract

Herpes simplex virus type 1 (HSV-1) is a globally widespread pathogen, and its increasing prevalence, associated complications, and emerging drug resistance underscore the need for novel antiviral agents. In this study, polysaccharide fractions were extracted from seven marine algae species collected from the El Jadida Atlantic Coast, Morocco, using aqueous and Soxhlet extraction methods. The antiviral activity of these extracts against HSV-1, as well as their cytotoxicity, was evaluated. All tested extracts demonstrated notable antiviral activity. Among them, the polysaccharide from Chondracanthus acicularis exhibited the strongest effect (IC₅₀= 17.78 ± 2.5 μg/mL), followed by the extract from Ellisolandia elongata (IC₅₀ = 18,12 ± 4,8 μg/mL). Importantly, none of the extracts showed cytotoxicity at the tested concentrations. These results highlight the potential of marine algal polysaccharides as antiviral agents and provide a basis for further studies on the chemical characterization and bioactivity of polysaccharides from marine macroalgae.