Table 1.
Change of hepatocyte distribution by ploidy classes with cold introduction on rats, %.
| Class cells | Control (n=7) | Exposure time, days | ||
|---|---|---|---|---|
| 3 (n=7) | 7 (n=8) | 14 (n=7) | ||
| 2C | 1.9 | 6.4* | 9.5* | 7.8* |
| 2 x 2C | 2.0 | 1.2* | 3.4 | 1.1 |
| 4C | 20.4 | 21.0 | 29.8* | 26.5* |
| 2 x 4C | 6.7 | 3.8* | 3.3* | 3.1* |
| 8C | 45.5 | 52.0* | 36.3* | 40.8* |
| 2 x 8C | 7.0 | 2.9* | 4.9 | 3.4* |
| >8C | 13.7 | 7.8* | 3.9* | 12.1 |
| 2 x >8C | 1.3 | 0.5 | 0.3* | 2.1 |
| “Synthesizing” cells | 1.6 | 4.4* | 8.6* | 3.1* |
| Binucleate cells | 16.9 | 8.8* | 12.7* | 9.7* |
| Average ploidy, C | 8.982 | 7.690 | 6.772 | 8.178 |
Note: C-equivalent of one set of chromosomes; “Synthesizing” – cells of intermediate classes (2C-4C, 4C-8C and also binuclear); mean ploidy was considered without taking “synthesizing” into account; *- reliable differences (p<0.05) using the chi2 criterion (800-1000 cell fluorescence was measured in each group).
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