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Table 3.
Morphometric analysis of the pancreatic islets of rats at 30 d after alloxan-induced diabetes and after lipoic acid injections
| Parameter | Young group N=10 | Old group (control) N=10 | Alloxan- induced diabetes N=10 | Alloxan-induced diabetes + lipoic acid N=10 |
|---|---|---|---|---|
| Number of pancreatic islets, N/mm2 | 1,8 ± 0,2 | 0,32±0,01 | 0,24±0,17,# | 0,72±0,1*,# |
| Average area of the islets, mcm2 | 13028±2089 | 24001±1370 | 18315±1200* | 17065,46± 2309,18*,# |
| Percent of pancreatic islets with positive insulin staining, % | 100± 0 | 87±2,4 | 49±1,07* | 69±6,1*,# |
| Number of cells in the pancreatic islets, N/mm2 | 8,67±0,24 | 6,54±3,2 | 2,31±2,8* | 8,16±2,42*,# |
| Number of β-cells in the pancreatic islets, N/mm2 | 7048 ± 246 | 5672±312 | 23,02±4,1* | 5934±512*,# |
| Percent of β-cells in the pancreatic islets, % | 81,3 ±1,7 | 86,73±23,57 | 0,99±0,001* | 42,1±11,9*,# |
| Optical density of cytoplasm in insulin+- cells in the islets of Langerhans | 0,56±0,01 | 0,48±0,02 | 0,35±0,01* | 0,41±0,03# |
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