Open Access
| Issue |
BIO Web Conf.
Volume 232, 2026
2026 16th International Conference on Bioscience, Biochemistry and Bioinformatics (ICBBB 2026)
|
|
|---|---|---|
| Article Number | 04008 | |
| Number of page(s) | 22 | |
| Section | Natural Products Pharmacology and Therapeutic Mechanisms | |
| DOI | https://doi.org/10.1051/bioconf/202623204008 | |
| Published online | 24 April 2026 | |
- H. Devarbhavi, SK. Asrani, JP. Arab, YA. Narte, et al. Global burden of liver disease: 2023 update. Journal of hepatology, 79(2), 516–537(2023). https://doi.org/10.1016/jjhep.2023.03.017) [Google Scholar]
- D. Razavi-Shearer, I. Gamkrelidze, C. Pan, et al. Global prevalence, cascade of care, and prophylaxis coverage of hepatitis B in 2022: a modelling study. The lancet. Gastroenterology & hepatology, 8(10), 879–907 (2023). https://doi.org/10.1016/S2468-1253(23)00197-8 [Google Scholar]
- C. Gan, Y. Yuan, H. Shen,. et al. Liver diseases: epidemiology, causes, trends and predictions. Sig Transduct Target Ther. 10, 33 (2025). https://doi.org/10.1038/s41392-024-02072-z [Google Scholar]
- Z. M. Younossi, P. Golabi, J. M. Paik, The global epidemiology of nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH): a systematic review. Hepatology (Baltimore, Md. ), 77(4), 1335–1347 (2023). https://doi.org/10.1097/HEP.0000000000000004 [Google Scholar]
- R. Loomba, S. L. Friedman, G. I. Shulman. Mechanisms and disease consequences of nonalcoholic fatty liver disease. Cell, 184(10), 2537–2564 (2021). https://doi.org/10.1016/j.cell.2021.04.015 [Google Scholar]
- P. Kasper, A. Martin, S. Lang, NAFLD and cardiovascular diseases: a clinical review. Clinical research in cardiology : official journal of the German Cardiac Society, 110(7), 921–937 (2021). https://doi.org/10.1007/s00392-020-01709-7 [Google Scholar]
- F. Åberg, Z. G Jiang, H. Cortez-Pinto, et al. Alcohol-associated liver disease-Global epidemiology. Hepatology (Baltimore, Md. ), 80(6), 1307–1322 (2024). https://doi.org/10.1097/HEP.0000000000000899 [Google Scholar]
- W. Liang, X. Huang, J. Shi. Macrophages Serve as Bidirectional Regulators and Potential Therapeutic Targets for Liver Fibrosis. Cell Biochem Biophys 81, 659–671 (2023). https://doi.org/10.1007/s12013-023-01173-wUSED2 [Google Scholar]
- F. D. Wang, J. Zhou, E. Q. Chen. Molecular Mechanisms and Potential New Therapeutic Drugs for Liver Fibrosis. Frontiers in pharmacology, 13, 787748 (2022). https://doi.org/10.3389/fphar.2022.787748 [Google Scholar]
- D. Ye, R. Jingyi, Y. Hongqiang. Roles of pathogen-associated and damage-associated molecular patterns in immune inflammatory response[J]. Inter J Stomatol, 2016, 43(2): 172–176. [Google Scholar]
- N. Nasiri-Ansari, T. Androutsakos, C. M. Flessa, et al. Endothelial Cell Dysfunction and Nonalcoholic Fatty Liver Disease (NAFLD): A Concise Review. Cells, 11(16), 2511 (2022)https://doi.org/10.3390/cells11162511 [Google Scholar]
- L. Ceci, E. Gaudio, L. Kennedy. Cellular Interactions and Crosstalk Facilitating Biliary Fibrosis in Cholestasis. Cellular and molecular gastroenterology and hepatology, 17(4), 553–565 (2024). https://doi.org/10.1016/jjcmgh.2024.01.005 [Google Scholar]
- C. Ding, Z. Wang, X. Dou, et al. Farnesoid X receptor: From Structure to Function and Its Pharmacology in Liver Fibrosis. Aging and disease, 15(4), 1508–1536(2024). https://doi.org/10.14336/AD.2023.0830 [Google Scholar]
- JL. Lu, CX. Yu, LJ. Song. Programmed cell death in hepatic fibrosis: current and perspectives. Cell Death Discov. 9, 449 (2023). https://doi.org/10.1038/s41420-023-01749-8 [Google Scholar]
- M. Robinson, C. Harmon, C. O'Farrelly. Liver immunology and its role in inflammation and homeostasis. Cell Mol Immunol 13, 267–276 (2016). https://doi.org/10.1038/cmi.2016.3 [Google Scholar]
- C. Ju, F. Tacke. Hepatic macrophages in homeostasis and liver diseases: from pathogenesis to novel therapeutic strategies. Cell Mol Immunol 13, 316–327 (2016). https://doi.org/10.1038/cmi.2015.104 [Google Scholar]
- D. R. Kamm, K. S. McCommis. Hepatic stellate cells in physiology and pathology. The Journal of physiology, 600(8), 1825–1837(2022)https://doi.org/10.1113/JP281061 [Google Scholar]
- A. E. Barry, R. Baldeosingh, R. Lamm, et al. Hepatic Stellate Cells and Hepatocarcinogenesis. Frontiers in cell and developmental biology, 8, 709 (2020). https://doi.org/10.3389/fcell.2020.00709 [Google Scholar]
- A. Sharip, J. Kunz. Mechanosignaling via Integrins: Pivotal Players in Liver Fibrosis Progression and Therapy. Cells, 14(4), 266(2025). https://doi.org/10.3390/cells14040266 [Google Scholar]
- M. Puri, S. Sonawane. Liver Sinusoidal Endothelial Cells in the Regulation of Immune Responses and Fibrosis in Metabolic Dysfunction-Associated Fatty Liver Disease. International journal of molecular sciences, 26(9), 3988(2025). https://doi.org/10.3390/ijms26093988 [Google Scholar]
- B. Gao, A. Waisman. Th17 cells regulate liver fibrosis by targeting multiple cell types: many birds with one stone. Gastroenterology, 143(3), 536–539(2012) https://doi.org/10.1053/j.gastro.2012.07.031 [Google Scholar]
- Y. J. Yang, F. Huang. Role of hepatic stellate cells and correlated cytokines in the formation of hepatic fibrosis. Shijie Huaren Xiaohua Zazhi 2007; 15(27): 2885–2890 [DOI: 10.11569/wcjd.v15.i27.2885]. [Google Scholar]
- CS. Pavlov, G. Casazza, D. Nikolova, et al. Transient elastography for diagnosis of stages of hepatic fibrosis and cirrhosis in people with alcoholic liver disease. Cochrane Database of Systematic Reviews 2015, Issue 1. Art. No.: CD010542. DOI: 10.1002/14651858.CD010542.pub2 [Google Scholar]
- R. Bataller, D. A. Brenner. Liver fibrosis. The Journal of clinical investigation, 115(2), 209–218 (2005). https://doi.org/10.1172/JCI24282 [Google Scholar]
- T. Kisseleva, D. Brenner. Molecular and cellular mechanisms of liver fibrosis and its regression. Nat Rev Gastroenterol Hepatol 18, 151–166 (2021). https://doi.org/10.1038/s41575-020-00372-7 [Google Scholar]
- M. Sun, T. Kisseleva. Reversibility of liver fibrosis. Clinics and research in hepatology and gastroenterology, 39 Suppl 1(01), S60-S63 (2015). https://doi.org/10.1016/j.clinre.2015.06.015 [Google Scholar]
- X. Ma, J. Qiu, S. Zou, et al. The role of macrophages in liver fibrosis: composition, heterogeneity, and therapeutic strategies. Frontiers in immunology, 15, 1494250(2024). https://doi.org/10.3389/fimmu.2024.1494250 [Google Scholar]
- Y. H. Li, Y. Zhang, G. Pan, et al. Occurrences and Functions of Ly6Chi and Ly6Clo Macrophages in Health and Disease. Frontiers in immunology, 13, 901672(2022). https://doi.org/10.3389/fimmu.2022.901672 [Google Scholar]
- E. Seki, R. F. Schwabe. Hepatic inflammation and fibrosis: functional links and key pathways. Hepatology (Baltimore, Md. ), 61(3), 1066–1079 (2015). https://doi.org/10.1002/hep.27332 [Google Scholar]
- A. Moreno-Lanceta, M. Medrano-Bosch, Y. Fundora,. RNF41 orchestrates macrophage-driven fibrosis resolution and hepatic regeneration. Science translational medicine, 15(704), eabq6225(2023).. https://doi.org/10.1126/scitranslmed.abq6225 [Google Scholar]
- J. S. Troeger, I. Mederacke, G. Y. Gwak, et al. Deactivation of hepatic stellate cells during liver fibrosis resolution in mice. Gastroenterology, 143(4), 1073–83. e22 (2012). https://doi.org/10.1053/j.gastro.2012.06.036 [Google Scholar]
- X. Dong, J. Liu, Y. Xu, et al. Role of macrophages in experimental liver injury and repair in mice. Experimental and therapeutic medicine, 17(5), 3835–3847(2019). https://doi.org/10.3892/etm.2019.7450 [Google Scholar]
- S. K. Wculek, G. Dunphy, I. Heras-Murillo, Metabolism of tissue macrophages in homeostasis and pathology. Cell Mol Immunol 19, 384–408 (2022). https://doi.org/10.1038/s41423-021-00791-9 [Google Scholar]
- Y. Wen, J. Lambrecht, C. Ju, et al. Hepatic macrophages in liver homeostasis and diseases-diversity, plasticity and therapeutic opportunities. Cell Mol Immunol 18, 45–56 (2021). https://doi.org/10.1038/s41423-020-00558-8 [Google Scholar]
- N. Wang, H. Liang, K. Zen. Molecular mechanisms that influence the macrophage m1-m2 polarization balance. Frontiers in immunology, 5, 614 (2014). https://doi.org/10.3389/fimmu.2014.00614 [Google Scholar]
- J. Xu, G. Núñez. The NLRP3 inflammasome: activation and regulation. Trends in biochemical sciences, 48(4), 331–344(2023). https://doi.org/10.1016/j.tibs.2022.10.002 [Google Scholar]
- T. Tsuchida, S. L. Friedman. Mechanisms of hepatic stellate cell activation. Nature reviews. Gastroenterology & hepatology, 14(7), 397–411 (2017). https://doi.org/10.1038/nrgastro.2017.38 [Google Scholar]
- X. Du, Z. Wu, Y. Xu, et al. Increased Tim-3 expression alleviates liver injury by regulating macrophage activation in MCD-induced NASH mice. Cellular & molecular immunology, 16(11), 878–886(2019). https://doi.org/10.1038/s41423-018-0032-0 [Google Scholar]
- T. Shan, L. Qian, C. Yang, et. al. (2021). Effect of interaction between hepatic macrophages and hepatic stellate cells on the occurrence and reversion of hepatic fibrosis. Chinese Bulletin of Life Sciences, 33(3), 363–373(2021). [Google Scholar]
- E. Seki, S. de Minicis, S. Inokuchi, et al. CCR2 promotes hepatic fibrosis in mice. Hepatology (Baltimore, Md. ), 50(1), 185–197. (2009). https://doi.org/10.1002/hep.22952 [Google Scholar]
- F. Marra, F. Tacke. Roles for chemokines in liver disease. Gastroenterology, 147(3), 577–594,(2014). e1. https://doi.org/10.1053/j.gastro.2014.06.043 [Google Scholar]
- E. Seki, S. De Minicis, G. Y. Gwak, et. al. CCR1 and CCR5 promote hepatic fibrosis in mice. The Journal of clinical investigation, 119(7), 1858–1870(2009). https://doi.org/10.1172/jci37444 [Google Scholar]
- R. Sasaki, P. B. Devhare, R. Steele, et. al. Hepatitis C virus-induced CCL5 secretion from macrophages activates hepatic stellate cells. Hepatology (Baltimore, Md. ), 66(3), 746–757(2017).. https://doi.org/10.1002/hep.29170 [Google Scholar]
- Y. S. Roh, E. Seki. Chemokines and Chemokine Receptors in the Development of NAFLD. Advances in experimental medicine and biology, 1061, 45–53(2018). https://doi.org/10.1007/978-981-10-8684-74 [Google Scholar]
- A. Ambade, P. Lowe, K. Kodys, et al. Pharmacological Inhibition of CCR2/5 Signaling Prevents and Reverses Alcohol-Induced Liver Damage, Steatosis, and Inflammation in Mice. Hepatology (Baltimore, Md. ), 69(3), 1105–1121(2019). https://doi.org/10.1002/hep.30249 [Google Scholar]
- E. Lefebvre, Moyle, G. Reshef, et al. Antifibrotic Effects of the Dual CCR2/CCR5 Antagonist Cenicriviroc in Animal Models of Liver and Kidney Fibrosis. PloS one, 11(6), e0158156 (2016). https://doi.org/10.1371/journal.pone.0158156 [Google Scholar]
- C. Wang, C. Ma, L. Gong, et al. Macrophage Polarization and Its Role in Liver Disease. Frontiers in immunology, 12, 803037(2021). https://doi.org/10.3389/fimmu.2021.803037 [Google Scholar]
- R. Chen, H. Zhang, B. Tang, et al. Macrophages in cardiovascular diseases: molecular mechanisms and therapeutic targets. Sig Transduct Target Ther 9, 130 (2024). https://doi.org/10.1038/s41392-024-01840-1 [Google Scholar]
- J. Chen, S. Zhang. The Role of Inflammation in Cholestatic Liver Injury. Journal of inflammation research, 16, 4527–4540(2023). https://doi.org/10.2147/JIR.S430730 [Google Scholar]
- Y. A. Ni, H. Chen, H. Nie, et al. HMGB1 : An overview of its roles in the pathogenesis of liver disease. Journal of leukocyte biology, 110(5), 987–998 (2021). https://doi.org/10.1002/JLB.3MR0121-277R [Google Scholar]
- W. Ying, M. Riopel, G. Bandyopadhyay, et al. Adipose Tissue Macrophage-Derived Exosomal miRNAs Can Modulate In Vivo and In Vitro Insulin Sensitivity. Cell, 171(2), 372–384. e12(2017). https://doi.org/10.1016/j.cell.2017.08.035 [Google Scholar]
- J. Wan, M. Benkdane, F. Teixeira-Clerc, et al. M2 Kupffer cells promote M1 Kupffer cell apoptosis: a protective mechanism against alcoholic and nonalcoholic fatty liver disease. Hepatology (Baltimore, Md. ), 59(1), 130–142 (2014).. https://doi.org/10.1002/hep.26607 [Google Scholar]
- L. J. Kitto, N. C. Henderson. Hepatic Stellate Cell Regulation of Liver Regeneration and Repair. Hepatology communications, 5(3), 358–370(2020). https://doi.org/10.1002/hep4.1628 [Google Scholar]
- A. Zisser, D. H. Ipsen, P. Tveden-Nyborg. Hepatic Stellate Cell Activation and Inactivation in NASH-Fibrosis—Roles as Putative Treatment Targets? Biomedicines, 9(4), 365(2021). https://doi.org/10.3390/biomedicines9040365 [Google Scholar]
- Y. Q. Zhao, X. W. Deng, G. Q. Xu, et al. Mechanical homeostasis imbalance in hepatic stellate cells activation and hepatic fibrosis. Frontiers in molecular biosciences, 10, 1183808 (2023). https://doi.org/10.3389/fmolb.2023.1183808 [Google Scholar]
- L. Hammerich, F. Tacke, Hepatic inflammatory responses in liver fibrosis. Nat Rev Gastroenterol Hepatol 20, 633–646 (2023). https://doi.org/10.1038/s41575-023-00807-x [Google Scholar]
- C. Y. Zhang, W. G. Yuan, P. He,et al. Liver fibrosis and hepatic stellate cells: Etiology, pathological hallmarks and therapeutic targets. World journal of gastroenterology, 22(48), 10512–10522(2016). https://doi.org/10.3748/wjg.v22.i48.10512 [Google Scholar]
- T. Tsuchida, S. Friedman. Mechanisms of hepatic stellate cell activation. Nat Rev Gastroenterol Hepatol 14, 397–411 (2017). https://doi.org/10.1038/nrgastro.2017.38 [Google Scholar]
- H. Z. Ying, Q. Chen, W. Y. Zhang, et al. PDGF signaling pathway in hepatic fibrosis pathogenesis and therapeutics (Review). Molecular medicine reports, 16(6), 7879–7889(2017). https://doi.org/10.3892/mmr.2017.7641 [Google Scholar]
- F. Rangwala, C. D. Guy, J. Lu, et al. Increased production of sonic hedgehog by ballooned hepatocytes. The Journal of pathology, 224(3), 401–410(2011). https://doi.org/10.1002/path.2888 [Google Scholar]
- D. Povero, N. Panera, A. Eguchi, et al. Lipid-induced hepatocyte-derived extracellular vesicles regulate hepatic stellate cell via microRNAs targeting PPAR-y. Cellular and molecular gastroenterology and hepatology, 1(6), 646–663. e4 (2015). https://doi.org/10.1016/j.jcmgh.2015.07.007 [Google Scholar]
- A. Herchenhan, F. Uhlenbrock, P. Eliasson, et al. Lysyl Oxidase Activity Is Required for Ordered Collagen Fibrillogenesis by Tendon Cells. The Journal of biological chemistry, 290(26), 16440–16450(2015). https://doi.org/10.1074/jbc.M115.641670 [Google Scholar]
- L. Wiering, P. Subramanian, L. & Hammerich. Hepatic Stellate Cells: Dictating Outcome in Nonalcoholic Fatty Liver Disease. Cellular and molecular gastroenterology and hepatology, 15(6), 1277–1292 (2023). https://doi.org/10.1016/j.jcmgh.2023.02.010 [Google Scholar]
- N. Frangogiannis. Transforming growth factor-ß in tissue fibrosis. The Journal of experimental medicine, 217(3), e20190103(2020). https://doi.org/10.1084/jem.20190103 [Google Scholar]
- J. Gong, J. Han, J. He, et al. Paired related homeobox protein 1 regulates PDGF-induced chemotaxis of hepatic stellate cells in liver fibrosis. Lab Invest 97, 1020–1032 (2017). https://doi.org/10.1038/labinvest.2017.65 [Google Scholar]
- Maeso-Díaz, R., & Gracia-Sancho, J. (2020). Aging and chronic liver disease. Seminars in Liver Disease, 40(4), 373–384. https://doi.org/10.1055/s-0040-1715446 [Google Scholar]
- S. P. Tang, X. L. Mao, Y. H. Chen, et al. Reactive Oxygen Species Induce Fatty Liver and Ischemia-Reperfusion Injury by Promoting Inflammation and Cell Death. Frontiers in immunology, 13, 870239(2022).. https://doi.org/10.3389/fimmu.2022.870239 [Google Scholar]
- N. Kelley, D. Jeltema, Y. Duan,et al. The NLRP3 Inflammasome: An Overview of Mechanisms of Activation and Regulation. International journal of molecular sciences, 20(13), 3328(2019). https://doi.org/10.3390/ijms20133328 [Google Scholar]
- S. Guo, Q. Zhang, Y. Guo, X. Yin. et al. The role and therapeutic targeting of the CCL2/CCR2 signaling axis in inflammatory and fibrotic diseases. Frontiers in immunology, 15, 1497026 (2025). https://doi.org/10.3389/fimmu.2024.1497026 [Google Scholar]
- S. Bouffette, I. Botez, F. De Ceuninck. Targeting galectin-3 in inflammatory and fibrotic diseases. Trends in pharmacological sciences, 44(8), 519–531 (2023). https://doi.org/10.1016/j.tips.2023.06.001 [Google Scholar]
- J. F. Calver, N. R. Parmar, G. Harris, et al. Defining the mechanism of galectin-3-mediated TGF-ß1 activation and its role in lung fibrosis. The Journal of biological chemistry, 300(6), 107300(2024). https://doi.org/10.1016/j.jbc.2024.107300 [Google Scholar]
- L. Zhao, H. Tang, Z. Cheng. Pharmacotherapy of Liver Fibrosis and Hepatitis: Recent Advances. Pharmaceuticals, 17(12), 1724 (2024)https://doi.org/10.3390/ph17121724 [Google Scholar]
- R. Nevola, R. Epifani, S. Imbriani, G. Tortorella,et al. GLP-1 Receptor Agonists in Non-Alcoholic Fatty Liver Disease: Current Evidence and Future Perspectives. International journal of molecular sciences, 24(2), 1703 (2023). https://doi.org/10.3390/ijms24021703 [Google Scholar]
- V. Ratziu, A. Sanyal, S. A. Harrison, et al. Cenicriviroc treatment for adults with nonalcoholic steatohepatitis and fibrosis: final analysis of the phase 2b CENTAUR study. Hepatology, 72(3), 892–905(2020). [Google Scholar]
- R. B. Holmgaard, D. A. Schaer, Y. Li, et al. Targeting the TGFß pathway with galunisertib, a TGFßRI small molecule inhibitor, promotes anti-tumor immunity leading to durable, complete responses, as monotherapy and in combination with checkpoint blockade. Journal for immunotherapy of cancer, 6(1), 47(2018). https://doi.org/10.1186/s40425-018-0356-4 [Google Scholar]
- Y. Aono, Y. Nishioka, M. Inayama, et al. Imatinib as a novel antifibrotic agent in bleomycin-induced pulmonary fibrosis in mice. American journal of respiratory and critical care medicine, 171(11), 1279–1285(2005). https://doi.org/10.1164/rccm.200404-531OC [Google Scholar]
- S. Dhani, Y. Zhao, B. Zhivotovsky. A long way to go: caspase inhibitors in clinical use. Cell death & disease, 12(10), 949 (2021). https://doi.org/10.1038/s41419-021-04240-3 [Google Scholar]
- S. Hwang, Y. He, X. Xiang, et al. Interleukin-22 Ameliorates Neutrophil-Driven Nonalcoholic Steatohepatitis Through Multiple Targets. Hepatology (Baltimore, Md. ), 72(2), 412–429(2020). https://doi.org/10.1002/hep.31031 [Google Scholar]
- H. Dai, C. Zhu, Q. Huai,et al. Chimeric antigen receptor-modified macrophages ameliorate liver fibrosis in preclinical models. Journal of hepatology, 80(6), 913–927 (2024)https://doi.org/10.1016/j.jhep.2024.01.034 [Google Scholar]
- S. Hiltbrunner, C. Britschgi, P. Schuberth, et al. Local delivery of CAR T cells targeting fibroblast activation protein is safe in patients with pleural mesothelioma: first report of FAPME, a phase I clinical trial. Annals of Oncology, 32(1), 120–121 (2021).. https://doi.org/10.5167/uzh-193552 [Google Scholar]
- A. Albillos, A. de Gottardi, M. Rescigno. The gut-liver axis in liver disease: Pathophysiological basis for therapy. Journal of hepatology, 72(3), 558–577(2020). https://doi.org/10.1016/j.jhep.2019.10.003 [Google Scholar]
- Y. Yan, Q. Lv, F. Zhou, et al. Discovery of an effective anti-inflammatory agent for inhibiting the activation of NF-kB. Journal of enzyme inhibition and medicinal chemistry, 38(1), 2225135 (2023). https://doi.org/10.1080/14756366.2023.2225135 [Google Scholar]
- F. Perner, H. L. Pahl, R. Zeiser, et al. Malignant JAK-signaling: at the interface of inflammation and malignant transformation. Leukemia 39, 1011–1030 (2025). https://doi.org/10.1038/s41375-025-02569-8 [Google Scholar]
- W. Ouyang, A. O'Garra. IL-10 Family Cytokines IL-10 and IL-22: from Basic Science to Clinical Translation. Immunity, 50(4), 871–891 (2019). https://doi.org/10.1016/j.immuni.2019.03.020 [Google Scholar]
- X. Song, C. Jiang, M. Yu, et al. CCR2/CCR5 antagonist cenicriviroc reduces colonic inflammation and fibrosis in experimental colitis. Journal of gastroenterology and hepatology, 39(8), 1597–1605(2024). https://doi.org/10.1111/jgh.16622 [Google Scholar]
- A. Gonzalez-Rodriguez, A. M. Valverde. RNA Interference as a Therapeutic Strategy for the Treatment of Liver Diseases. Current pharmaceutical design, 21(31), 4574–4586(2015). https://doi.org/10.2174/138161282131151013190740 [Google Scholar]
- Z. Q. Yao, M. B. Schank, J. Zhao, et al. The potential of HBV cure: an overview of CRISPR-mediated HBV gene disruption. Frontiers in genome editing, 6, 1467449(2024)https://doi.org/10.3389/fgeed.2024.1467449 [Google Scholar]
- P. Dalsbecker, C. Beck Adiels, M. Goksör. Liver-on-a-chip devices: the pros and cons of complexity. American journal ofphysiology. Gastrointestinal and liver physiology, 323(3), G188-G204(2022). https://doi.org/10.1152/ajpgi.00346.2021 [Google Scholar]
- K. Somnay, P. Wadgaonkar, N. Sridhar, et al. Liver Fibrosis Leading to Cirrhosis: Basic Mechanisms and Clinical Perspectives. Biomedicines, 12(10), 2229(2024). https://doi.org/10.3390/biomedicines12102229 [Google Scholar]
- S. Hafeez, M. H. Ahmed. Bariatric surgery as potential treatment for nonalcoholic fatty liver disease: a future treatment by choice or by chance?. Journal of obesity, 2013, 839275(2013). https://doi.org/10.1155/2013/839275 [Google Scholar]
- Y. Liu, C. Meyer, C. Xu, et al. Animal models of chronic liver diseases. American journal of physiology. Gastrointestinal and liver physiology, 304(5), G449-G468(2013)https://doi.org/10.1152/ajpgi.00199.2012 [Google Scholar]
- J. Li, B. Tuo. Current and Emerging Approaches for Hepatic Fibrosis Treatment. Gastroenterology research and practice, 2021, 6612892, (2021). https://doi.org/10.1155/2021/6612892 [Google Scholar]
- X. Li, Y. Liu, Y. Tang, et al. Transformation of macrophages into myofibroblasts in fibrosis-related diseases: emerging biological concepts and potential mechanism. Frontiers in immunology, 15, 1474688(2024). https://doi.org/10.3389/fimmu.2024.1474688 [Google Scholar]
- S. Shetty, P. F. Lalor, D. H. Adams, Liver sinusoidal endothelial cells — gatekeepers of hepatic immunity. Nat Rev Gastroenterol Hepatol 15, 555–567 (2018). https://doi.org/10.1038/s41575-018-0020-y [Google Scholar]
- Z. J. Brown, B. Heinrich, T. F. Greten. Mouse models of hepatocellular carcinoma: an overview and highlights for immunotherapy research. Nature reviews. Gastroenterology & hepatology, 15(9), 536–554, (2018). https://doi.org/10.1038/s41575-018-0033-6 [Google Scholar]
- L. J. Kitto, N. C. Henderson. Hepatic Stellate Cell Regulation of Liver Regeneration and Repair. Hepatology communications, 5(3), 358–370 (2020). https://doi.org/10.1002/hep4.1628 [Google Scholar]
- X. Dong, J. Liu, Y. Xu, et al. Role of macrophages in experimental liver injury and repair in mice. Experimental and therapeutic medicine, 17(5), 3835–3847(2019). https://doi.org/10.3892/etm.2019.7450 [Google Scholar]
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