Open Access
Issue
BIO Web Conf.
Volume 237, 2026
2026 8th International Conference on Biotechnology and Biomedicine (ICBB 2026)
Article Number 02001
Number of page(s) 9
Section Pharmacology, Natural Products and Drug Delivery
DOI https://doi.org/10.1051/bioconf/202623702001
Published online 10 June 2026
  • X. Jianguo, Treatment of acute pain. J. Clin. Anesthesiol. 12 (04), 32 (1996) (in Chinese) [Google Scholar]
  • L. Qian, L. Jian, Progress in opioid treatment of chronic moderate-to-severe cancer pain. Chin. J. Pain Med. 17 (02), 116 (2011) (in Chinese) [Google Scholar]
  • A.H. Rogers, S.G. Farris, A meta-analysis of the associations of elements of the fear-avoidance model of chronic pain with negative affect, depression, anxiety, pain-related disability and pain intensity. Eur. J. Pain 26, 1611 (2022) [Google Scholar]
  • M.H. Ossipov, K. Morimura, F. Porreca, Descending pain modulation and chronification of pain. Curr. Opin. Support. Palliat. Care 8, 143 (2014) [Google Scholar]
  • V.P. Mathis, A.T. Ehrlich, E. Darcq, The neural circuits and signalling pathways of opioid use disorder. Nat. Rev. Neurosci. 26, 778 (2025) [Google Scholar]
  • T. Geng, Chinese scientists reveal mechanisms of potent analgesics fentanyl and morphine. Shanghai Sci. Technol. News (2022) (in Chinese) [Google Scholar]
  • X. Li, Y. Dong, H. Li et al., Opioid tolerance and opioid therapy for chronic cancer pain. Chin. J. Pain Med. 18, 561 (2012) (in Chinese) [Google Scholar]
  • N.N. Umukoro, B.W. Aruldhas, R. Rossos et al., Pharmacogenomics of oxycodone: a narrative literature review. Pharmacogenomics 22, 275 (2021) [Google Scholar]
  • L.S. Lima, N.S. da Costa, M.E.A. Galiciolli et al., Assessment of Neurotoxic Effects of Oxycodone and Naloxone in SH-SY5Y Cell Line. Int. J. Mol. Sci. 24, 1424 (2023) [Google Scholar]
  • R. Klimas, G. Mikus, Morphine-6-glucuronide is responsible for the analgesic effect after morphine administration: a quantitative review of morphine, morphine-6-glucuronide, and morphine-3-glucuronide. Br. J. Anaesth. 113, 935 (2014) [Google Scholar]
  • P.F.J. Lipiński, M. Jarończyk, J.C. Dobrowolski, J. Sadlej, Molecular dynamics of fentanyl bound to μ-opioid receptor. J. Mol. Model. 25, 144 (2019) [Google Scholar]
  • K. Zhu, X. Wen, X. Mei, F. Fang, T. Zhang, Mechanisms of Remifentanil-Induced Postoperative Hyperalgesia: A Comprehensive Review. Drug Des. Devel. Ther. 19, 7445 (2025) [Google Scholar]
  • N.P. Patel, C.M. Bates, A. Patel, Developmental Approaches to Chronic Pain: A Narrative Review. Cureus 15, e45238 (2023) [Google Scholar]
  • F. Fiatcoski, C.H.A. Jesus, J. de Melo Turnes et al., Sex differences in descending control of nociception (DCN) responses after chronic orofacial pain induction in rats and the contribution of kappa opioid receptors. Behav. Brain Res. 459, 114789 (2024) [Google Scholar]
  • P. Kaczmarski, F.F. Karuga, B. Szmyd et al., The Role of Inflammation, Hypoxia, and Opioid Receptor Expression in Pain Modulation in Patients Suffering from Obstructive Sleep Apnea. Int. J. Mol. Sci. 23, 9080 (2022) [Google Scholar]
  • Q. Chen, P. Sahbaie, K.A. Irvine, J.D. Clark, Mild Traumatic Brain Injury–Induced Augmented Postsurgical Pain Is Driven by Central Serotonergic Pain-Facilitatory Signaling. Anesth. Analg. 138, 866 (2024) [Google Scholar]
  • M. García-Domínguez, A Comprehensive Analysis of Fibromyalgia and the Role of the Endogenous Opioid System. Biomedicines 13, 165 (2025) [Google Scholar]
  • J. Tour, A. Sandström, D. Kadetoff et al., The OPRM1 gene and interactions with the 5-HT1a gene regulate conditioned pain modulation in fibromyalgia patients and healthy controls. PLoS One 17, e0277427 (2022) [Google Scholar]
  • R. Tzadok, J.N. Ablin, Current and Emerging Pharmacotherapy for Fibromyalgia. Pain Res. Manag. 2020, 6541798 (2020) [Google Scholar]
  • M. Hein, G. Ji, D. Tidwell et al., Kappa opioid receptor activation in the amygdala disinhibits CRF neurons to generate pain-like behaviors. Neuropharmacology 185, 108456 (2021) [Google Scholar]
  • V. Neugebauer, M. Mazzitelli, B. Cragg et al., Amygdala, neuropeptides, and chronic pain-related affective behaviors. Neuropharmacology 170, 108052 (2020) [Google Scholar]
  • L. Wang, K. Hou, H. Wang, F. Fu, L. Yu, Role of mu-opioid receptor in nociceptive modulation in anterior cingulate cortex of rats. Mol. Pain 16, 1744806920966144 (2020) [Google Scholar]
  • V. Neugebauer, P. Presto, V. Yakhnitsa et al., Pain-related cortico-limbic plasticity and opioid signaling. Neuropharmacology 231, 109510 (2023) [Google Scholar]
  • E. Navratilova, K. Nation, B. Remeniuk et al., Selective modulation of tonic aversive qualities of neuropathic pain by morphine in the central nucleus of the amygdala requires endogenous opioid signaling in the anterior cingulate cortex. Pain 161, 609 (2020) [Google Scholar]
  • Y. Du, Y. Zhao, A. Zhang et al., The Role of the Mu Opioid Receptors of the Medial Prefrontal Cortex in the Modulation of Analgesia Induced by Acute Restraint Stress in Male Mice. Int. J. Mol. Sci. 25, 9774 (2024) [Google Scholar]
  • W. Kim, M.C. Angulo, Unraveling the role of oligodendrocytes and myelin in pain. J. Neurochem. 169, e16206 (2025) [Google Scholar]
  • W. Wu, A. Qiao, T. Du, Tissue-specific mechanism of estrogen in osteoporosis and vascular calcification. Eur. J. Pharmacol. 1002, 177783 (2025) [Google Scholar]
  • S. Garcia Guerra, A. Spadoni, J. Mitchell, I.A. Strigo, Pain-related opioidergic and dopaminergic neurotransmission: Dual meta-Analyses of PET radioligand studies. Brain Res. 1805, 148268 (2023) [Google Scholar]
  • W. Fujita, The Possible Role of MOPr-DOPr Heteromers and Its Regulatory Protein RTP4 at Sensory Neurons in Relation to Pain Perception. Front. Cell. Neurosci. 14, 609362 (2020) [Google Scholar]
  • M. García-Domínguez, κ-Opioid Receptor Agonists as Robust Pain-Modulating Agents: Mechanisms and Therapeutic Potential in Pain Modulation. J. Clin. Med. 14, 7263 (2025) [Google Scholar]
  • A.H. Dickenson, E. Navratilova, R. Patel, F. Porreca, K. Bannister, Supraspinal Opioid Circuits Differentially Modulate Spinal Neuronal Responses in Neuropathic Rats. Anesthesiology 132, 881 (2020) [Google Scholar]
  • K.B. McPherson, S.L. Ingram, Cellular and circuit diversity determines the impact of endogenous opioids in the descending pain modulatory pathway. Front. Syst. Neurosci. 16, 963812 (2022) [Google Scholar]
  • H. Imbe, H. Ihara, Mu opioid receptor expressing neurons in the rostral ventromedial medulla are the source of mechanical hypersensitivity induced by repeated restraint stress. Brain Res. 1815, 148465 (2023) [Google Scholar]
  • I. Tavares, J.T. Costa-Pereira, I. Martins, Monoaminergic and Opioidergic Modulation of Brainstem Circuits: New Insights Into the Clinical Challenges of Pain Treatment. Front. Pain Res. (Lausanne) 2, 696515 (2021) [Google Scholar]
  • M. Pagliusi Jr, F.V. Gomes, The Role of The Rostral Ventromedial Medulla in Stress Responses. Brain Sci. 13, 776 (2023) [Google Scholar]
  • S.T. Lubejko, G. Livrizzi, S.A. Buczynski et al., Inputs to the locus coeruleus from the periaqueductal gray and rostroventral medulla shape opioid-mediated descending pain modulation. Sci. Adv. 10, eadj9581 (2024) [Google Scholar]
  • I. Tavares, J.T. Costa-Pereira, I. Martins, Monoaminergic and Opioidergic Modulation of Brainstem Circuits: New Insights Into the Clinical Challenges of Pain Treatment. Front. Pain Res. (Lausanne) 2, 696515 (2021) [Google Scholar]
  • A.R. Costa, I. Tavares, I. Martins, How do opioids control pain circuits in the brainstem during opioid-induced disorders and in chronic pain? Implications for the treatment of chronic pain. Pain 165, 324 (2024) [Google Scholar]
  • T. Hiroki, T. Suto, J. Ohta, S. Saito, H. Obata, Spinal γ-Aminobutyric Acid Interneuron Plasticity Is Involved in the Reduced Analgesic Effects of Morphine on Neuropathic Pain. J. Pain 23, 547 (2022) [Google Scholar]
  • Y. Bai, M.Y. Li, J.B. Ma et al., Enkephalinergic Circuit Involved in Nociceptive Modulation in the Spinal Dorsal Horn. Neuroscience 429, 78 (2020) [Google Scholar]
  • B.F.G. Queiroz, W.C.P. Barra, F.C.S. Fonseca et al., Dopaminergic and Opioid Systems Interact to Produce Peripheral Antinociception in Mice. J. Integr. Neurosci. 24, 44311 (2025) [Google Scholar]
  • H. Machelska, M.Ö. Celik, Opioid Receptors in Immune and Glial Cells—Implications for Pain Control. Front. Immunol. 11, 300 (2020) [Google Scholar]
  • S.Y. Lim, P. Cengiz, Opioid tolerance and opioid-induced hyperalgesia: Is TrkB modulation a potential pharmacological solution? Neuropharmacology 220, 109260 (2022) [Google Scholar]
  • H. Javid, A. Rezayof, Z. Ghasemzadeh, M. Sardari, The involvement of ventral hippocampal microglial cells, but not cannabinoid CB1 receptors, in morphine-induced analgesia in rats. Acta Neurol. Belg. 120, 1077 (2020) [Google Scholar]
  • M. de Melo Cardoso, R. Scussel, J. da Silva Abel et al., Intravenous administration of recombinant Phα1β: Antinociceptive properties and morphine tolerance reversal in a cancer-associated pain model. Toxicon 243, 107717 (2024) [Google Scholar]
  • J. Liu, R. Dai, R. Damiescu, T. Efferth, D.Y.W. Lee, Role of Levo-tetrahydropalmatine and its metabolites for management of chronic pain and opioid use disorders. Phytomedicine 90, 153594 (2021) [Google Scholar]
  • L. Hohenwarter, R. Böttger, S.D. Li, Modification and Delivery of Enkephalins for Pain Modulation. Int. J. Pharm. 646, 123425 (2023) [Google Scholar]
  • M. García-Domínguez, Enkephalins and Pain Modulation: Mechanisms of Action and Therapeutic Perspectives. Biomolecules 14, 926 (2024) [Google Scholar]
  • L. Hughes, S.D. Patterson, The effect of blood flow restriction exercise on exercise-induced hypoalgesia and endogenous opioid and endocannabinoid mechanisms of pain modulation. J. Appl. Physiol. (1985) 128, 914 (2020) [Google Scholar]
  • P.F.J. Lipiński, J. Matalińska, Fentanyl Structure as a Scaffold for Opioid/Non-Opioid Multitarget Analgesics. Int. J. Mol. Sci. 23, 2766 (2022) [Google Scholar]
  • G. Zhang, M. Cui, R. Ji et al., Neural and molecular investigation into the paraventricular thalamic-nucleus accumbens circuit for pain sensation and non-opioid analgesia. Pharmacol. Res. 191, 106776 (2023) [Google Scholar]
  • S. Sullere, A. Kunczt, D.S. McGehee, A cholinergic circuit that relieves pain despite opioid tolerance. Neuron 111, 3414 (2023) [Google Scholar]
  • N.J. van den Hoogen, E.K. Harding, C.E.D. Davidson, T. Trang, Cannabinoids in Chronic Pain: Therapeutic Potential Through Microglia Modulation. Front. Neural Circuits 15, 816747 (2022) [Google Scholar]
  • A.L. Milligan, T.A. Szabo-Pardi, M.D. Burton, Cannabinoid Receptor Type 1 and Its Role as an Analgesic: An Opioid Alternative? J. Dual Diagn. 16, 106 (2020) [Google Scholar]
  • Y. Cao, Z. Wu, M. Zhang et al., Microglial adenosine A2A receptor in the paraventricular thalamic nucleus regulates pain sensation and analgesic effects independent of opioid and cannabinoid receptors. Front. Pharmacol. 15, 1467305 (2024) [Google Scholar]
  • M. Kim, M. López-Cano, K. Zhang et al., Wireless, battery-free, remote photoactivation of caged-morphine for photopharmacological pain modulation without side effects. Biosens. Bioelectron. 281, 117440 (2025) [Google Scholar]
  • K.B. McPherson, S.L. Ingram, Cellular and circuit diversity determines the impact of endogenous opioids in the descending pain modulatory pathway. Front. Syst. Neurosci. 16, 963812 (2022) [Google Scholar]
  • E. Navratilova, K. Nation, B. Remeniuk et al., Selective modulation of tonic aversive qualities of neuropathic pain by morphine in the central nucleus of the amygdala requires endogenous opioid signaling in the anterior cingulate cortex. Pain 161, 609 (2020) [Google Scholar]

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