Microbial Platforms for Converting Non-Food Renewable Biomass into Value-Added Chemicals and Materials: Progress over the Past Decade

Open Access

Issue		BIO Web Conf. Volume 237, 2026 2026 8^th International Conference on Biotechnology and Biomedicine (ICBB 2026)


Article Number		03008
Number of page(s)		9
Section		Biomaterials, Medical Devices and Biomedical Engineering
DOI		https://doi.org/10.1051/bioconf/202623703008
Published online		10 June 2026

International Energy Agency, 2025. Global energy review 2025. Paris: IEA. [Google Scholar]
Gu, D., Andreev, K., Dupre, M.E., 2021. Major trends in population growth around the world. China CDC Wkly. 3, 604–613. [Google Scholar]
Aguilar, A., Twardowski, T., Wohlgemuth, R., 2019. Bioeconomy for sustainable development. Biotechnol. J. 14, e1800638. [Google Scholar]
Tian, Y., Shan, M., Kong, G., Ma, L., Shao, S., 2021. Development strategy of biomass economy in China. Strateg. Study Chin. Acad. Eng. 23, 133–140. [Google Scholar]
Bin Sajid, H., Afzal, A., Fatima, S., Tabassum, N., Hamza Awan, M., Asif Raheem, M., 2023. An overview on synthetic biology: its classification, engineering approaches, and applications of synthetic biology. Asian J. Basic Sci. Res. 5, 40–49. [Google Scholar]
Food and Agriculture Organization of the United Nations, International Fund for Agricultural Development, United Nations Children’s Fund, World Food Programme, World Health Organization, 2025. The state of food security and nutrition in the world 2025: addressing high food price inflation for food security and nutrition. Rome: FAO, IFAD, UNICEF, WFP, WHO. [Google Scholar]
Lycourghiotis, S., Kordouli, E., 2025. Biomass conversion to value-added chemicals and fuels using natural minerals as catalysts or catalytic supports. Catalysts 15, 1006. [Google Scholar]
Sun, M., Gao, A.X., Liu, X., Bai, Z., Wang, P., Ledesma-Amaro, R., 2024. Microbial conversion of ethanol to high-value products: progress and challenges. Biotechnol. Biofuels Bioprod. 17, 115. [Google Scholar]
Shahzad, H.M.A., Asim, Z., Khan, S.J., Almomani, F., Mahmoud, K.A., Mustafa, M.R.U., et al., 2024. Thermochemical and biochemical conversion of agricultural waste for bioenergy production: an updated review. Discov. Environ. 2, 134. [Google Scholar]
Woźniak, A., Kuligowski, K., Świerczek, L., Cenian, A., 2025. Review of lignocellulosic biomass pretreatment using physical, thermal and chemical methods for higher yields in bioethanol production. Sustainability 17, 287. [Google Scholar]
Phillip, A., Goyal, B., 2024. Algal biofuels: a comprehensive review and analysis. J. Appl. Life Sci. Int. 27, 52–72. [Google Scholar]
Segers, B., Nimmegeers, P., Spiller, M., Tofani, G., Jasiukaitytė-Grojzdek, E., Dace, E., et al., 2024. Lignocellulosic biomass valorisation: a review of feedstocks, processes and potential value chains and their implications for the decision-making process. RSC Sustain. 2, 3730–3749. [Google Scholar]
Mehmood, M.A., Amin, M., Haider, M.N., Malik, S., Malik, H.A., Alam, M.A., et al., 2024. Wastewater-grown algal biomass as carbon-neutral, renewable, and low water footprint feedstock for clean energy and bioplastics. Curr. Pollut. Rep. 10, 172–188. [Google Scholar]
Hasnain Qamar, S.H.Q., Moazzam Ali, M., Ur Rehman, H., 2024. Comprehensive review of bioenergy sustainability: balancing economic, environmental, and social impacts. J. Lat. Am. Sci. Cult. 6, 47–65. [Google Scholar]
Mustafa, A., Faisal, S., Singh, J., Rezki, B., Kumar, K., Moholkar, V.S., et al., 2024. Converting lignocellulosic biomass into valuable end products for decentralized energy solutions: a comprehensive overview. Sustain. Energy Technol. Assess. 72, 104065. [Google Scholar]
Ingle, A.P., Saxena, S., Moharil, M.P., Rivaldi, J.D., Ramos, L., Chandel, A.K., 2025. Production of biomaterials and biochemicals from lignocellulosic biomass through sustainable approaches: current scenario and future perspectives. Biotechnol. Sustain. Mater. 2, 3. [Google Scholar]
Zoppi, G., Tito, E., Bianco, I., Pipitone, G., Pirone, R., Bensaid, S., 2023. Life cycle assessment of the biofuel production from lignocellulosic biomass in a hydrothermal liquefaction – aqueous phase reforming integrated biorefinery. Renew. Energy 206, 375–385. [Google Scholar]
Mankar, A.R., Pandey, A., Modak, A., Pant, K.K., 2021. Pretreatment of lignocellulosic biomass: a review on recent advances. Bioresour. Technol. 334, 125235. [Google Scholar]
Usmani, Z., Sharma, M., Gupta, P., Karpichev, Y., Gathergood, N., Bhat, R., et al., 2020. Ionic liquid based pretreatment of lignocellulosic biomass for enhanced bioconversion. Bioresour. Technol. 304, 123003. [CrossRef] [Google Scholar]
Yan, X., He, Q., Geng, B., Yang, S., 2024. Microbial cell factories in the bioeconomy era: from discovery to creation. BioDes. Res. 6, 0052. [Google Scholar]
Milessi, T.S., Reis, C.E., Ramos, M.D.N., Carvalho, A.K.F., Aminabhavi, T., Chandel, A.K., 2025. Native and tailor-made microbial cell factories for economic production of bio-renewables: a paradigm shift in industrial biotechnology. Biomass Bioenergy 201, 108097. [Google Scholar]
Ravagnan, G., Schmid, J., 2024. Promising non- model microbial cell factories obtained by genome reduction. Front. Bioeng. Biotechnol. 12, 1427248. [Google Scholar]
Lin, K., Han, S., Zheng, S., 2022. Application of Corynebacterium glutamicum engineering display system in three generations of biorefinery. Microb. Cell Fact. 21, 14. [Google Scholar]
Mitsui, R., Yamada, R., 2021. Chapter 16 - Saccharomyces cerevisiae as a microbial cell factory, in: Singh, V. (Ed.), Microbial Cell Factories Engineering for Production of Biomolecules. Academic Press, pp. 319–333. [Google Scholar]
Li, K., Sun, M.-L., Yuan, B., Li, C., Zhao, X.-Q., Liu, C.-G., et al., 2025. Engineering Corynebacterium glutamicum cell factory for producing biochemicals. BioDes. Res. 7, 100008. [Google Scholar]
Branduardi, P., 2021. Closing the loop: the power of microbial biotransformations from traditional bioprocesses to biorefineries, and beyond. Microb. Biotechnol. 14, 68–73. [Google Scholar]
Jeong, K.J., 2025. Advancing microbial engineering through synthetic biology. J. Microbiol. 63, e2503100. [Google Scholar]
Cho, J.S., Kim, G.B., Eun, H., Moon, C.W., Lee, S.Y., 2022. Designing microbial cell factories for the production of chemicals. JACS Au 2, 1781–1799. [Google Scholar]
Olayiwola, A.O., Dalhatu, A., Oyewole, O.M., Oke, G.O., Ogunniyi, T.J., Ademikanra, A.F., 2023. Metabolic engineering of microbial cell factories for sustainable biomanufacturing. Biomed. Chem. Sci. 2, 33–45. [Google Scholar]
Sadanov, A.K., Baimakhanova, B.B., Orasymbet, S.E., Ratnikova, I.A., Turlybaeva, Z.Z., Baimakhanova, G.B., et al., 2025. Engineering useful microbial species for pharmaceutical applications. Microorganisms 13, 599. [Google Scholar]
Gurdo, N., Volke, D.C., McCloskey, D., Nikel, P.I., 2023. Automating the design-build-test-learn cycle towards next-generation bacterial cell factories. New Biotechnol. 74, 1–15. [Google Scholar]
Lou, H., Hu, L., Lu, H., Wei, T., Chen, Q., 2021. Metabolic engineering of microbial cell factories for biosynthesis of flavonoids: a review. Molecules 26. [Google Scholar]
Sagharyan, M., Mohammadbagherlou, S., Samari, E., Zargar, M., Ghorbani, A., Chen, M., 2025. Synthetic biology and metabolic engineering strategies in identifying and producing plant natural products; with emphasis on the CRISPR/Cas systems. Ind. Crops Prod. 230, 121060. [Google Scholar]
Ayan, G., Sibashish, B., 2023. CRISPR/Cas9 technology: challenges and drawbacks. J. Adv. Zool. 44, 1965–1971. [Google Scholar]
Presnell, K.V., Alper, H.S., 2019. Systems metabolic engineering meets machine learning: a new era for data-driven metabolic engineering. Biotechnol. J. 14, e1800416. [Google Scholar]
Du, J., Shao, Z., Zhao, H., 2011. Engineering microbial factories for synthesis of value-added products. J. Ind. Microbiol. Biotechnol. 38, 873–890. [Google Scholar]
Guragain, Y.N., Vadlani, P.V., 2021. Renewable biomass utilization: a way forward to establish sustainable chemical and processing industries. Clean Technol. 3, 243–259. [Google Scholar]
Yang, P., Jiang, S., Lu, S., Jiang, S., Jiang, S., Deng, Y., et al., 2022. Ethanol yield improvement in Saccharomyces cerevisiae GPD2 ΔFPS1 ΔADH2 ΔDLD3 Δmutant and molecular mechanism exploration based on the metabolic flux and transcriptomics approaches. Microb. Cell Fact. 21, 160. [Google Scholar]
Tsegaye, K.N., Alemnew, M., Berhane, N., 2024. Saccharomyces cerevisiae for lignocellulosic ethanol production: a look at key attributes and genome shuffling. Front. Bioeng. Biotechnol. 12, 1466644. [Google Scholar]
Khamwachirapithak, P., Sae-Tang, K., Mhuantong, W., Tanapongpipat, S., Zhao, X.-Q., Liu, C.-G., et al., 2023. Optimizing ethanol production in Saccharomyces cerevisiae at ambient and elevated temperatures through machine learning-guided combinatorial promoter modifications. ACS Synth. Biol. 12, 2897–2908. [Google Scholar]
Kumar, K., Jadhav, S.M., Moholkar, V.S., 2024. Acetone-butanol-ethanol (ABE) fermentation with clostridial co-cultures for enhanced biobutanol production. Process Saf. Environ. Prot. 185, 277–285. [Google Scholar]
Massadeh, M.I., Alsharafat, O., Saleem, A., Damat, D., Suherman, S., Setyobudi, R.H., 2023. Butanol production by Clostridium acetobutylicum NCIMB 13357 utilizing yeast industry wastewater as a fermentation medium. E3S Web Conf. 2023, 00022. [Google Scholar]
Oehlenschläger, K., Hengsbach, J.-N., Volkmar, M., Ulber, R., 2025. From pre-culture to solvent: current trends in Clostridium acetobutylicum cultivation. Appl. Microbiol. Biotechnol. 109, 47. [Google Scholar]
Lee, J.-S., Lin, C.-J., Lee, W.-C., Teng, H.-Y., Chuang, M.-H., 2022. Production of succinic acid through the fermentation of Actinobacillus succinogenes on the hydrolysate of Napier grass. Biotechnol. Biofuels Bioprod. 15, 9. [Google Scholar]
Casella, P., Loffredo, R., Rao, M.A., Balducchi, R., Liuzzi, F., De Bari, I., et al., 2024. Inhibitors derived from wheat straw hydrolysate can affect the production of succinic acid by Actinobacillus succinogenes. Process Biochem. 147, 228–239. [Google Scholar]
Zheng, P., Zhou, W., Ni, Y., Jiang, M., Wei, P., Sun, Z., 2008. Environmental factors affecting the succinic acid production by Actinobacillus succinogenes CGMCC 1593. Sheng Wu Gong Cheng Xue Bao 24, 1051–1055. [Google Scholar]
Gundlapalli, M., Ganesan, S., 2025. Polyhydroxyalkanoates (PHAs): key challenges in production and sustainable strategies for cost reduction within a circular economy framework. Results Eng. 26, 105345. [Google Scholar]
Hathi, Z.J., Haque, M.A., Priya, A., Qin, Z.-h., Huang, S., Lam, C.H., et al., 2022. Fermentative bioconversion of food waste into biopolymer poly(3-hydroxybutyrate-co-3-hydroxyvalerate) using Cupriavidus necator. Environ. Res. 215, 114323. [Google Scholar]
Senila, L., Gál, E., Kovacs, E., Cadar, O., Dan, M., Senila, M., et al., 2023. Poly(3-hydroxybutyrate) production from lignocellulosic wastes using Bacillus megaterium ATCC 14581. Polymers 15, 4488. [Google Scholar]
Kamasaka, K., Abekawa, N., Takeda, K., Noi, K., Matsuda, M., Matsumoto, K., et al., 2025. Monitoring proliferation and material production of Cupriavidus necator H16 using cell count and volume measurement. Sci. Rep. 15, 30416. [Google Scholar]
Deng, L., Su, C., Wu, Y., Xue, Q., Zhang, C., Wang, Y., et al., 2025. High-titer L-lactic acid production by fed-batch simultaneous saccharification and fermentation of steam-exploded corn stover. Fermentation 11, 25. [Google Scholar]
Kuo, Y.-C., Yuan, S.-F., Wang, C.-A., Huang, Y.-J., Guo, G.-L., Hwang, W.-S., 2015. Production of optically pure L-lactic acid from lignocellulosic hydrolysate by using a newly isolated and D-lactate dehydrogenase gene-deficient Lactobacillus paracasei strain. Bioresour. Technol. 198, 651–657. [Google Scholar]
Li, W., Huang, X., Liu, H., Lian, H., Xu, B., Zhang, W., et al., 2023. Improvement in bacterial cellulose production by co-culturing Bacillus cereus and Komagataeibacter xylinus. Carbohydr. Polym. 313, 120892. [Google Scholar]
Sharma, P., Sharma, R., Yadav, A., Aggarwal, N.K., 2025. Sustainable and cost-effective production of bacterial cellulose by using rice straw hydrolysate: a response surface approach. Braz. J. Microbiol. 56, 1543–1553. [Google Scholar]
Li, M., Liu, C., Yang, J., Nian, R., Xian, M., Li, F., et al., 2020. Common problems associated with the microbial productions of aromatic compounds and corresponding metabolic engineering strategies. Biotechnol. Adv. 41, 107548. [Google Scholar]
Muñoz-Fernández, G., Martínez-Buey, R., Revuelta, J.L., Jiménez, A., 2022. Metabolic engineering of Ashbya gossypii for limonene production from xylose. Biotechnol. Biofuels Bioprod. 15, 79. [Google Scholar]
Zhao, Y., Zhang, Y., Nielsen, J., Liu, Z., 2021. Production of β-carotene in Saccharomyces cerevisiae through altering yeast lipid metabolism. Biotechnol. Bioeng. 118, 2043–2052. [Google Scholar]
Ayodele, T., Alarape, K., Bello, I.A., Tijani, A., Musiliu, L., Hammed, A., 2024. Microbial protein production using lignocellulosic biomass (switchgrass) and Klebsiella oxytoca M5A1—a nitrogen fixer. Sustainability 16, 5486. [Google Scholar]
Shishparenok, A.N., Furman, V.V., Dobryakova, N.V., Zhdanov, D.D., 2024. Protein immobilization on bacterial cellulose for biomedical application. Polymers 16, 2468. [Google Scholar]

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