| Issue |
BIO Web Conf.
Volume 8, 2017
2016 International Conference on Medicine Sciences and Bioengineering (ICMSB2016)
|
|
|---|---|---|
| Article Number | 02010 | |
| Number of page(s) | 5 | |
| Section | Session II: Bioinformatics | |
| DOI | https://doi.org/10.1051/bioconf/20170802010 | |
| Published online | 11 January 2017 | |
Analysis of genotype effects for the immunosuppression via two-step method
1 School of Information Engineering, Harbin University, Harbin 150086, China
2 School of Mathematical Sciences, Heilongjiang University, Harbin 150080, China
a Corresponding author: yzhou@aliyun.com
This paper studies the main effects and interactive effects between genes on immunosuppression susceptibility caused by ultraviolet radiation in population of mice. We present a two-step strategy, i.e., we first establish one full linear model based on all main effects and interactive effects, and use the Dantzig selector method to screen the genotype effects preliminary; then via the idea of stepwise regression, under the other model we further detect the significant main effects and interactive effects for the UV-induced immunosuppression susceptibility. The most significant main effect site that we identified is D10Mit170, and the most significant interactive sites are D6Mit389 and D16Mit131.
© The Authors, published by EDP Sciences, 2017
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