| Issue |
BIO Web Conf.
Volume 17, 2020
International Scientific-Practical Conference “Agriculture and Food Security: Technology, Innovation, Markets, Human Resources” (FIES 2019)
|
|
|---|---|---|
| Article Number | 00061 | |
| Number of page(s) | 5 | |
| DOI | https://doi.org/10.1051/bioconf/20201700061 | |
| Published online | 28 February 2020 | |
Pharmacoprophylaxis of liver diseases: creating a new hepatoprotector
1
Perm Military Institute of National Guard Troops, 614112 Perm, Russia
2
Perm State National Research University, 614990 Perm, Russia
3
Samara state agrarian University, 446442 Kinel, Samara region, Russia
4
Kuban State Agrarian University, 305044 Krasnodar, Russia
5
Moscow Institute of Physics and Technology, 141701 Dolgoprudny, Moscow Region, Russia
* Corresponding author: zykova.sv@rambler.ru
The article presents a study of the hepatoprotective activity of a tricyclic heterocycle, which refers to 5, 6, 7, 8-tetrahydroquinolines. The effect of 8, 8-dimethyl-5-p-tolyl-8, 9-dihydro-2H-pyrido [4, 3, 2-de] cinnolin-3 (7H) was studied on rats under the influence of the model of toxic hepatosis induced by carbon tetrachloride to find out the indicators of peroxidation and biochemical indicators. Biochemical studies have shown that modelling toxic fat hepatosis caused by the inception of carbon tetrachloride to rats increased the activity of alanine aminotransferase by 2.5 times more compared with the intact group, indicating the development of oxidative stress induced by the treatment of pyrido [4, 3, 2] Cinnol I that reduced the toxic effect of CTC by 79.9 %. Mexidol had a less pronounced hepatoprotective effect: the activity of Alanine aminotransferase on animals of the second group was lower by 29.2 % than on rats from the control group. Thus, a new compound with hepatoprotective activity has been developed and studied.
© The Authors, published by EDP Sciences, 2020
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