| Issue |
BIO Web Conf.
Volume 40, 2021
III International Symposium “Innovations in Life Sciences” (ILS 2021)
|
|
|---|---|---|
| Article Number | 01002 | |
| Number of page(s) | 10 | |
| Section | Fundamental and Applied Aspects of Biology and Biotechnology | |
| DOI | https://doi.org/10.1051/bioconf/20214001002 | |
| Published online | 20 December 2021 | |
Wound-healing activity of immobilized postbiotics from Bacillus subtilis exometabolites
Al-Farabi Kazakh National University, 050040, Almaty, Kazakhstan
* Corresponding author: dina_ibrayeva_91@mail.ru
The biological activity of postbiotic from Bacillus subtilis exometabolites was determined due to protein content - 0.541±13.4 mg/ml, the level of proteases - 7.8±0.3 U/ml and the presence of antimicrobial substances. A biocomposite material was developed by co-aggregation of bacterial cellulose, chitosan and Bacillus exometabolites. Modified BC gel film possesses high antagonistic activity against causative agents of wound infections: Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, Staphylococcus epidermidis. The use of the obtained material in treatment of wounds on laboratory animals reduces healing time by an average of 20%. The developed bioactive wound dressings is intended for local application in order to optimize the wound healing process.
Key words: Bacillus subtilis / postbiotics / antagonistic activity
© The Authors, published by EDP Sciences, 2021
This is an Open Access article distributed under the terms of the Creative Commons Attribution License 4.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Current usage metrics show cumulative count of Article Views (full-text article views including HTML views, PDF and ePub downloads, according to the available data) and Abstracts Views on Vision4Press platform.
Data correspond to usage on the plateform after 2015. The current usage metrics is available 48-96 hours after online publication and is updated daily on week days.
Initial download of the metrics may take a while.