| Issue |
BIO Web Conf.
Volume 60, 2023
2022 4th International Conference on Biotechnology and Food Science (BFS 2022)
|
|
|---|---|---|
| Article Number | 01011 | |
| Number of page(s) | 6 | |
| Section | Biochemical Application and Genetic Engineering | |
| DOI | https://doi.org/10.1051/bioconf/20236001011 | |
| Published online | 11 May 2023 | |
The Application of CRISPR-Cas System in Glioblastoma Research and Treatment
The University of Melbourne, Grattan Street, Parkville, Victoria, 3010, Australia
* Corresponding author: jiaqfeng@student.unimelb.edu.au
Glioblastoma is a malignant brain cancer with high mortality. Currently, there is no effective treatment that can effectively improve the survival of patients. Traditional gene editing tools, such as Zinc finger nuclease, RNAi and translational activator-like effector nucleases (TALENTS), have shown their advantages in treating glioblastoma. However, they have the disadvantages of high cost and difficult to operate. In recent years, with the discovery and development of the CRISPR-Cas system, its easy to design, inexpensive, and high flexibility make it gradually become a widely used gene editing tool and provide a strong boost for the research of glioblastoma. This article reviews the recent literature and summarizes the application of the CRISPR Cas system in the model establishment and therapy development of glioblastoma.
© The Authors, published by EDP Sciences, 2023
This is an Open Access article distributed under the terms of the Creative Commons Attribution License 4.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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