Issue |
BIO Web Conf.
Volume 155, 2025
10th-ICCC – 10th International Conference on Climate Change “Climate Change, Plant and Health”
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Article Number | 10003 | |
Number of page(s) | 8 | |
Section | Climate Change Impact on Health and Adaptation/Mitigation Strategy | |
DOI | https://doi.org/10.1051/bioconf/202515510003 | |
Published online | 29 January 2025 |
The impact of environmental factors on the immunopathogenesis of osteoporosis: A systematic review
1 Doctoral Program of Medical Sciences, Faculty of Medicine, Universitas Sebelas Maret, 57126, Suarakarta, Indonesia
2 Obstetrics and Gynecology Department, Faculty of Medicine, Universitas Sebelas Maret, 57126, Suarakarta, Indonesia
3 Biochemistry Department, Faculty of Medicine, Universitas Sebelas Maret, 57126, Suarakarta, Indonesia
4 Clinicopathologic Department, Faculty of Medicine, Universitas Sebelas Maret, 57126, Suarakarta, Indonesia
5 Public Health Department, Faculty of Medicine, Universitas Sebelas Maret, 57126, Suarakarta, Indonesia
6 Internal Medicine Department, Faculty of Medicine, Universitas Sebelas Maret, 57126, Suarakarta, Indonesia
7 Parasitology Department, Faculty of Medicine, Universitas Sebelas Maret, 57126, Suarakarta, Indonesia
* Corresponding author: dr.Nurhasan21@staff.uns.ac.id
Osteoporosis is a metabolic bone disease predominantly driven by environmental variables that damage bone microarchitecture and increase the risk of fractures. This systematic study analyzes environmental variables' impact on osteoporosis immunopathogenesis. We identified studies investigating the relationship between air pollution, heavy metal exposure, and chemical exposure with immune activity in osteoporosis through searches in PubMed databases. The review's findings indicate that exposure to environmental pollutants triggers systemic inflammation and oxidative stress, contributing to an imbalance between bone formation and resorption. Fine particulate matter (PM2.5) and nitrogen dioxide (NO2) pollutants are linked to reduced bone mineral density and a heightened risk of osteoporosis. This study underscores the importance of preventive strategies and public health policies that consider reducing environmental pollutant exposure to decrease osteoporosis risk. The results further emphasise the necessity for targeted interventions to safeguard at-risk individuals against the detrimental impacts of environmental variables on bone health.
© The Authors, published by EDP Sciences, 2025
This is an Open Access article distributed under the terms of the Creative Commons Attribution License 4.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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