Research advances in the protective effect of sulforaphane against kidney injury and related mechanisms

Open Access

Issue		BIO Web Conf. Volume 55, 2022 5^th International Conference on Frontiers of Biological Sciences and Engineering (FBSE 2022)


Article Number		01006
Number of page(s)		6
DOI		https://doi.org/10.1051/bioconf/20225501006
Published online		21 November 2022

Rapa, S.F., Di Iorio, B.R., Campiglia, P., Heidland, A.&Marzocco, S. Inflammation and Oxidative Stress in Chronic Kidney Disease-Potential Therapeutic Role of Minerals, Vitamins and Plant-Derived Metabolites. Int J Mol Sci 21 (1)(2019). https://doi.org/10.3390/ijms21010263 [CrossRef] [Google Scholar]
Duni, A., Liakopoulos, V., Roumeliotis, S., Peschos, D. & Dounousi, E. Oxidative Stress in the Pathogenesis and Evolution of Chronic Kidney Disease: Untangling Ariadne’s Thread. Int J Mol Sci 20 (15)(2019). https://doi.org/10.3390/ijms20153711 [CrossRef] [Google Scholar]
Daenen, K. et al. Oxidative stress in chronic kidney disease. Pediatr Nephrol 34 (6):975-991 (2019). https://doi.org/10.1007/s00467-018-4005-4 [CrossRef] [PubMed] [Google Scholar]
Pizzino, G. et al. Oxidative Stress: Harms and Benefits for Human Health. Oxid Med Cell Longev 2017: 8416763 (2017). https://doi.org/10.1155/2017/8416763 [PubMed] [Google Scholar]
Subedi, L., Cho, K., Park, Y.U., Choi, H.J.&Kim, S.Y. Sulforaphane-Enriched Broccoli Sprouts Pretreated by Pulsed Electric Fields Reduces Neuroinflammation and Ameliorates Scopolamine-Induced Amnesia in Mouse Brain through Its Antioxidant Ability via Nrf2-HO-1 Activation. Oxid Med Cell Longev 2019: 3549274 (2019). https://doi.org/10.1155/2019/3549274 [PubMed] [Google Scholar]
Kang, K.W., Lee, S.J.&Kim, S.G. Molecular mechanism of nrf2 activation by oxidative stress. Antioxid Redox Signal 7(11-12): 1664-1673 (2005). https://doi.org/10.1089/ars.2005.7.1664 [CrossRef] [PubMed] [Google Scholar]
[7] Jomova, K.&Valko, M. Advances in metal-induced oxidative stress and human disease. Toxicology 283 (2-3):65-87 (2011). https://doi.org/10.1016/j.tox.2011.03.001 [CrossRef] [PubMed] [Google Scholar]
Li.J et al. Protective effect of sulforaphane on renal damage caused by cadmium in rats. Chinese Journal of Industrial Medicine 28 (01):11-13+42 (2015). https://doi.org/10.13631/j.cnki.zggyyx.2015.01.003 [Google Scholar]
Genchi, G., Sinicropi, M.S., Lauria, G., Carocci, A.&Catalano, A. The Effects of Cadmium Toxicity. Int J Environ Res Public Health 17 (11)(2020). https://doi.org/10.3390/ijerph17113782 [Google Scholar]
Uruno, A.&Motohashi, H. The Keap1-Nrf2 system as an in vivo sensor for electrophiles. Nitric Oxide 25 (2):153-160 (2011). https://doi.org/10.1016/j.niox.2011.02.007 [CrossRef] [PubMed] [Google Scholar]
Wakabayashi, N. et al. Protection against electrophile and oxidant stress by induction of the phase 2 response: fate of cysteines of the Keap1 sensor modified by inducers. Proc Natl Acad Sci U S A 101 (7):2040-2045 (2004). https://doi.org/10.1073/pnas.0307301101 [CrossRef] [PubMed] [Google Scholar]
Guo, M. et al. Protective effect of sulforaphane on mercuryinduced acute renal injury in rats. Practical Preventive Medicine 23(12): 1461-1464 (2016). [Google Scholar]
Zheng S. & Zhou J. Progress in the study of the nephrotoxicity mechanism of inorganic mercury (mercuric chloride). Medicine Abroad (Health Sciences Division) (03): 175-179 (2005). [Google Scholar]
Shen, M. etal. Effects of Tetracycline on the Expression of CaSR and Claudin-14 in Nanobacteria-infected Human Renal Tubular Epithelial Cells HK-2. China Pharmacy 29(19): 2607-2611 (2018). [Google Scholar]
Pu, D. et al. Effects of sulforaphane on mitophagy-related proteins in nanobacteria-induced renal tubular epithelial cell apoptosis. Journal of Clinical Rehabilitative Tissue Engineering Research 23(34): 5503-5507 (2019). [Google Scholar]
Li, L. & Tang J. Regulatory effects of sulforaphane on epithelial to mesenchymal transition in renal tubular epithelial cell through Traf6/TAK1 signaling pathway. International Journal of Urology and Nephrology|Int J Urol Nephrol (02): 305-306-307-308-309 (2020). [Google Scholar]
Qin Z. & Mao W. Effects of Sulforaphane on Oxidative Stress and Nrf2/HO-1 Signaling Pathway in Renal Tubular Epithelial Cells. China Pharmacist 20(05): 809-812 (2017). [Google Scholar]
Huang L. Liao P. & Zhang J. Sulforaphane attenuates renal ischemia reperfusion injury in mice by Nrf-2 against inflammation. Jounal of Xi’an Jiaotong University(Medical Sciences) 40 (05):696-701 (2019). [Google Scholar]
Shokeir, A.A. et al. Activation of Nrf2 by ischemic preconditioning and sulforaphane in renal ischemia/reperfusion injury: a comparative experimental study. Physiol Res 64 (3):313-323 (2015). https://doi.org/10.33549/physiolres.932834 [CrossRef] [PubMed] [Google Scholar]
Li, J. Pathogenesis and Chinese medicine treatment of acute kidney injury in sepsis. Nei Mongol Journal of Traditional Chinese Medicine. 41(04):150-153 (2022). https://doi.org/10.16040/j.cnki.cn15-1101. 2022.04.088 [Google Scholar]
Tang, L. et al. Protective effect of sulforaphane on oxidative response in rats with sepsis-associated acute kidney injury. Chinese Journal of Critical Care Medicine (Electronic Edition) 14(03): 187-191 (2021). [Google Scholar]
Zheng, H. et al. Therapeutic potential of Nrf2 activators in streptozotocin-induced diabetic nephropathy. Diabetes 60 (11):3055-3066 (2011). https://doi.org/10.2337/db11-0807 [CrossRef] [PubMed] [Google Scholar]
Shang, G. et al. Sulforaphane attenuation of experimental diabetic nephropathy involves GSK-3 beta/Fyn/Nrf2 signaling pathway. J Nutr Biochem 26 (6):596-606 (2015). https://doi.org/10.1016/j.jnutbio.2014.12.008 [CrossRef] [PubMed] [Google Scholar]
Khaleel, S.A. et al. Contrast media (meglumine diatrizoate) aggravates renal inflammation, oxidative DNA damage and apoptosis in diabetic rats which is restored by sulforaphane through Nrf2/HO-1 reactivation. Chem Biol Interact 309: 108689 (2019). https://doi.org/10.1016/j.cbi.2019.06.002 [CrossRef] [PubMed] [Google Scholar]
Wu, H. et al. Metallothionein plays a prominent role in the prevention of diabetic nephropathy by sulforaphane via upregulation of Nrf2. Free Radic Biol Med 89: 431-442 (2015). https://doi.org/10.1016/j.freeradbiomed.2015.08.009 [CrossRef] [PubMed] [Google Scholar]
Cui, W. et al. Prevention of diabetic nephropathy by sulforaphane: possible role of Nrf2 upregulation and activation. Oxid Med Cell Longev 2012: 821936 (2012). https://doi.org/10.1155/2012/821936 [PubMed] [Google Scholar]
Mohammad, R.S., Lokhandwala, M.F. & Banday, A.A. Age-Related Mitochondrial Impairment and Renal Injury Is Ameliorated by Sulforaphane via Activation of Transcription Factor NRF2. Antioxidants (Basel) 11(1) (2022). https://doi.org/10.3390/antiox11010156 [PubMed] [Google Scholar]
Scalco, R.S. et al. Rhabdomyolysis: a genetic perspective. Orphanet J Rare Dis 10: 51 (2015). https://doi.org/10.1186/s13023-015-0264-3 [CrossRef] [PubMed] [Google Scholar]
Lernoux, M., Schnekenburger, M., Dicato, M. & Diederich, M. Anti-cancer effects of naturally derived compounds targeting histone deacetylase 6-related pathways. Pharmacol Res 129: 337-356 (2018). https://doi.org/10.1016/j.phrs.2017.11.004 [CrossRef] [PubMed] [Google Scholar]
Tan J. & Yi G. Turnip-sulfur-mediated HDAC6 signaling pathway ameliorates myoglobin-induced apoptosis in renal tubular epithelial cells. Journal of Chinese Medicinal Materials 42 (09):2181-2184 (2019). https://doi.org/10.13863/j.issn1001-4454.2019.09.042 [Google Scholar]
Krukowski, K. et al. HDAC6 inhibition effectively reverses chemotherapy-induced peripheral neuropathy. Pain 158 (6):1126-1137 (2017). https://doi.org/10.1097/j.pain.0000000000000893 [CrossRef] [PubMed] [Google Scholar]
Tan J. & Yi G. Effect of sulforaphane alleviates uric acidinduced apoptosis in tubular epithelial cells via regulating endoplasmic reticulum stress and its mechanism. International Journal of Urology and Nephrology|Int J Urol Nephrol 40(04): 688-692 (2020). [Google Scholar]
Tang, S.C. & Lai, K.N. The pathogenic role of the renal proximal tubular cell in diabetic nephropathy. Nephrol Dial Transplant 27 (8):3049-3056 (2012). https://doi.org/10.1093/ndt/gfs260 [CrossRef] [PubMed] [Google Scholar]
Ren J. et al. Sulforaphane and Its Derivative BSFN Induced Apoptosis in SH-SY5Y Cells by Activating the PI3K/Akt Signaling Pathway. Chinese Pharmaceutical Journal | Chin Pharm J 49(20): 1813-1819 (2014). [Google Scholar]
Zhou, L. et al. Effects of Sulforaphane on the Proliferation and Apoptosis of Human Renal Tubular Epithelial Cells Induced by High Glucose and Its Mechanism. Chinese Pharmacy 32(24): 3000-3007 (2021). [Google Scholar]
Liu, R.T. et al. Effect and Mechanism of Sulforaphane on Calcium Oxalate Nephrolithiasis in Rats Through Nrf2 Signaling Pathway. Progress in Modern Biomedicine 22(11):2028-2033 (2022). https://doi.org/10.13241/j.cnki.pmb.2022.11.005 [Google Scholar]
Meng, X.M., Nikolic-Paterson, D.J. & Lan, H.Y. TGF-β: the master regulator of fibrosis. Nat Rev Nephrol 12 (6):325-338 (2016). https://doi.org/10.1038/nrneph.2016.48 [CrossRef] [PubMed] [Google Scholar]
Yin, Q. et al. Synthesis and photophysical properties of deuteration of pirfenidone. Spectrochim Acta A Mol Biomol Spectrosc 204: 88-98 (2018). https://doi.org/10.1016/j.saa.2018.06.016 [CrossRef] [PubMed] [Google Scholar]
Guo,L. et al. Interventional effect and mechanism of sulforaphane on renal fibrosis induced by unilateral ureteral obstruction in mice. Shandong Medical Journal 59(32): 33-36 (2019). [Google Scholar]
Sun, B. et al. Hippuric Acid Promotes Renal Fibrosis by Disrupting Redox Homeostasis via Facilitation of NRF2- KEAP1-CUL3 Interactions in Chronic Kidney Disease. Antioxidants (Basel) 9 (9)(2020). https://doi.org/10.3390/antiox9090783 [PubMed] [Google Scholar]
Leisti, S. et al. Association of postmedication hypocortisolism with early first relapse of idiopathic nephrotic syndrome. Lancet 2 (8042):795-796 (1977). https://doi.org/10.1016/s0140-6736(77)90726-7 [CrossRef] [Google Scholar]
Du, Z.H., M, H.H. & Long, Q. Effect of sulforaphane on mesangial cell proliferation in nephrotic syndrome rats through TGF β/Smad3 signaling pathway. Medical Journal of West China 32 (01):43-48 (2020). [CrossRef] [Google Scholar]

Current usage metrics show cumulative count of Article Views (full-text article views including HTML views, PDF and ePub downloads, according to the available data) and Abstracts Views on Vision4Press platform.

Data correspond to usage on the plateform after 2015. The current usage metrics is available 48-96 hours after online publication and is updated daily on week days.

Initial download of the metrics may take a while.