Open Access
Issue
BIO Web Conf.
Volume 59, 2023
2023 5th International Conference on Biotechnology and Biomedicine (ICBB 2023)
Article Number 01003
Number of page(s) 8
Section Biotechnology and Cell Structure Analysis
DOI https://doi.org/10.1051/bioconf/20235901003
Published online 08 May 2023
  • Wani, M. C., Taylor, H. L., Wall, M. E., Coggon, P. & Mcphail, A. T. Plant antitumor agents.VI. The isolation and structure of Taxol, a novel antileukemic and antitumor agent from Taxus brevifolia2. J. Am. Chem. Soc. 93, 2325–2327 (1971). [CrossRef] [PubMed] [Google Scholar]
  • McGuire, W. P. et al. Taxol: A unique antineoplastic agent with significant activity in advanced ovarian epithelial neoplasms. Ann. Intern. Med. 111, 273–279 (1989). [CrossRef] [PubMed] [Google Scholar]
  • Rowinsky, E. K., Cazenave, L. A. & Donehower, R. C. Taxol: a novel investigational antimicrotubule agent. J. Natl Cancer Inst. 82, 1247–1259 (1990). [CrossRef] [PubMed] [Google Scholar]
  • Holmes, F. A. et al. Phase II trial of Taxol, an active drug in the treatment of metastatic breast cancer. J. Natl Cancer Inst. 83, 1797–1805 (1991). [CrossRef] [PubMed] [Google Scholar]
  • Wani, M.C., and Horwitz, S.B. (2014). Nature as a remarkable chemist: a personal story of the discovery and development of Taxol. Anti Cancer Drug 25:482–487. [CrossRef] [PubMed] [Google Scholar]
  • Hu Y.J., Gu C.C., Wang X.F., Min L., Li C.C. (2021). Asymmetric Total Synthesis of Taxol. J Am Chem Soc. 143(42):17862–17870. [CrossRef] [PubMed] [Google Scholar]
  • Li Y., Zhang G., Pfeifer B.A. Current and emerging options for taxol production. Adv Biochem Eng Biotechnol, 2015, 148: 405. [PubMed] [Google Scholar]
  • Liu W.C., Gong T., Zhu P. Advances in exploring alternative taxol sources. RSC Adv, 2016, 6: 48800. [CrossRef] [Google Scholar]
  • Ro D.K., Paradise E.M., Ouellet M., et al. Production of the antimalarial drug precursor artemisinic acid in engineered yeast. Nature, 2006, 440(7086): 940–943. [CrossRef] [PubMed] [Google Scholar]
  • Yan X., Fan Y., Wei W., et al. Production of bioactive ginsenoside compound K in metabolically engineered yeast. Cell Res, 2014, 24(6): 770–773. [CrossRef] [PubMed] [Google Scholar]
  • Ajikumar P.K., Xiao W.H., Tyo K.E.J., et al. Isoprenoid pathway optimization for taxol precursor overproduction in Escherichia coli. Science, 2010, 330(6000): 70–74. [CrossRef] [PubMed] [Google Scholar]
  • Engels B., Dahm P., Jennewein S. Metabolic engineering of taxadiene biosynthesis in yeast as a first step towards Taxol (Paclitaxel) production[J]. Metabolic Engineering, 2008, 10(4):201–206. [Google Scholar]
  • Navia-Osorio A., Garden H., Cusido R.M., et al. Production of paclitaxel and baccatin III in a 20-L airlift bioreactor by a cell suspension of Taxus wallichiana. Planta Med, 2002, 68: 336–340. [CrossRef] [PubMed] [Google Scholar]
  • Stierle A., Strobel G., Stierle D. Taxol and taxane production by Taxomyces andreanae, an endophytic fungus of Pacific yew[J]. Science, 1993, 260(5105): 214–216. [CrossRef] [PubMed] [Google Scholar]
  • Ji Y., Bi J.N., Yan B., et al. Taxol-producing fungi: a new approach to industrial production of taxol. Chin J Biotechnol, 2006, 22: 1–6. [CrossRef] [Google Scholar]
  • Eisenreich, W., Menhard, B., Hylands, P.J., Zenk, M.H. and Bacher, A. (1996) Studies on the biosynthesis of taxol: the taxane carbon skeleton is not of mevalonoid origin. Proc. Natl Acad. Sci. USA, 93, 6431–6436. [CrossRef] [PubMed] [Google Scholar]
  • Walker, K. and Croteau, R. (2000) Taxol biosynthesis: molecular cloning of a benzoyl- CoA:taxane 2alpha-O-benzoyltransferase cDNA from Taxus and functional expression in Escherichia coli. Proc. Natl Acad. Sci. USA, 97, 13591–13596. [CrossRef] [PubMed] [Google Scholar]
  • Kaspera, R. and Croteau, R. (2006) Cytochrome P450 oxygenases of Taxol biosynthesis. Phytochem. Rev. 5, 433–444. [CrossRef] [PubMed] [Google Scholar]
  • Onrubia, M., Moyano, E., Bonfill, M., Palazon, J., Goossens, A. and Cusido, R.M. (2011) The relationship between TXS, DBAT, BAPT and DBTNBT gene expression and taxane production during the development of Taxus baccata plantlets. Plant Sci. 181, 282–287. [CrossRef] [Google Scholar]
  • Chau, M., and Croteau, R. (2004). Molecular cloning and characterization of a cytochrome P450 taxoid 2alpha-hydroxylase involved in Taxol biosynthesis. Arch. Biochem. Biophys. 427:48–57. [CrossRef] [Google Scholar]
  • Wildung, M.R., and Croteau, R. (1996). A cDNA clone for taxadiene synthase, the diterpene cyclase that catalyzes the committed step of taxol biosynthesis. J. Biol. Chem. 271:9201–9204. [CrossRef] [Google Scholar]
  • Chau, M., and Croteau, R. (2004). Molecular cloning and characterization of a cytochrome P450 taxoid 2alpha-hydroxylase involved in Taxol biosynthesis. Arch. Biochem. Biophys. 427:48–57. [CrossRef] [Google Scholar]
  • Jennewein, S., Long, R.M., Williams, R.M., and Croteau, R. (2004). Cytochrome p450 taxadiene 5alpha-hydroxylase, a mechanistically unusual monooxygenase catalyzing the first oxygenation step of taxol biosynthesis. Chem. Biol. 11:379–387. [CrossRef] [Google Scholar]
  • Chau, M., Jennewein, S., Walker, K., and Croteau, R. (2004). Taxol biosynthesis: molecular cloning and characterization of a cytochrome P450 taxoid 7 betahydroxylase. Chem. Biol. 11:663–672. [Google Scholar]
  • Schoendorf, A., Rithner, C.D., Williams, R.M., and Croteau, R.B. (2001). Molecular cloning of a cytochrome P450 taxane 10 betahydroxylase cDNA from Taxus and functional expression in yeast. Proc. Natl. Acad. Sci. U S A 98:1501–1506. [CrossRef] [PubMed] [Google Scholar]
  • Jennewein, S., Rithner, C.D., Williams, R.M., and Croteau, R.B. (2001). Taxol biosynthesis: taxane 13 alpha-hydroxylase is a cytochrome P450-dependent monooxygenase. Proc. Natl. Acad. Sci. U S A 98:13595–13600. [CrossRef] [PubMed] [Google Scholar]
  • Walker, K., Schoendorf, A., and Croteau, R. (2000). Molecular cloning of a taxa-4(20),11(12)-dien- 5alpha-ol-O-acetyl transferase cDNA from Taxus and functional expression in Escherichia coli. Arch. Biochem. Biophys. 374:371–380. [CrossRef] [Google Scholar]
  • Walker, K., and Croteau, R. (2000a). Taxol biosynthesis: molecular cloning of a benzoyl- CoA:taxane 2alpha-O-benzoyltransferase cDNA from taxus and functional expression in Escherichia coli. Proc. Natl. Acad. Sci. U S A 97:13591–13596. [CrossRef] [PubMed] [Google Scholar]
  • Walker, K., and Croteau, R. (2000b). Molecular cloning of a 10-deacetylbaccatin III-10-O-acetyl transferase cDNA from Taxus and functional expression in Escherichia coli. Proc. Natl. Acad. Sci. U S A 97:583–587. [CrossRef] [PubMed] [Google Scholar]
  • Walker, K., Fujisaki, S., Long, R., and Croteau, R. (2002a). Molecular cloning and heterologous expression of the C-13 phenylpropanoid side chain- CoA acyltransferase that functions in Taxol biosynthesis. Proc. Natl. Acad. Sci. U S A 99:12715–12720. [CrossRef] [PubMed] [Google Scholar]
  • Walker, K., Long, R., and Croteau, R. (2002b). The final acylation step in taxol biosynthesis: cloning of the taxoid C13-side-chain Nbenzoyltransferase from Taxus. Proc. Natl. Acad. Sci. U S A 99:9166–9171. [CrossRef] [PubMed] [Google Scholar]
  • Walker, K.D., Klettke, K., Akiyama, T., and Croteau, R. (2004). Cloning, heterologous expression, and characterization of a phenylalanine aminomutase involved in Taxol biosynthesis. J. Biol. Chem. 279:53947–53954. [CrossRef] [Google Scholar]
  • Sanchez-Muñoz, R., Perez-Mata, E., Almagro, L., Cusido, R.M., Bonfill, M., Palazon, J., and Moyano, E. (2020). A novel hydroxylation step in the taxane biosynthetic pathway: a new approach to paclitaxel production by synthetic biology. Front. Bioeng. Biotechnol. 8:410. [CrossRef] [Google Scholar]
  • Sorokina M., Merseburger P., Rajan K., et al. COCONUT online: collection of open natural products database[J]. Journal of Cheminformatics, 2021, 13(1): 1–13. [CrossRef] [PubMed] [Google Scholar]
  • Banerjee P., Erehman J., Gohlke B.O., et al. Super Natural II—a database of natural products[J]. Nucleic acids research, 2015, 43(D1): D935–D939. [CrossRef] [PubMed] [Google Scholar]
  • Cuthbertson D.J., Johnson S.R., Piljac-Žegarac J., et al. Accurate mass-time tag library for LC/MS-based metabolite profiling of medicinal plants[J]. Phytochemistry, 2013, 91: 187–197. [CrossRef] [PubMed] [Google Scholar]
  • Fischedick J.T., Johnson S.R., Ketchum R.E.B., et al. NMR spectroscopic search module for Spektraris, an online resource for plant natural product identification - Taxane diterpenoids from Taxus x media cell suspension cultures as a case study[J]. Phytochemistry, 2015, 113:87–95. [CrossRef] [PubMed] [Google Scholar]

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