Antitumor effects of table grape extracts

¹ CREA-VE, Research Centre for Viticulture and Enology, Council for Agricultural Research and Economics, Turi (BA) 70010, Italy
² Laboratory of Nutritional Biochemistry, National Institute of Gastroenterology Saverio de Bellis, IRCCS Research Hospital, Castellana Grotte (BA) 70013, Italy
³ Ambulatory of Clinical Nutrition, National Institute of Gastroenterology Saverio de Bellis, IRCCS Research Hospital, Castellana Grotte (BA) 70013, Italy
⁴ Scientific Secretary of the Subcommittee Table Grapes, Raisins and Unfermented Grape Products- OIV, International Organization of Vine and Wine, Paris – Dijon, France

Abstract

Grape (Vitis vinifera L.) is a fruit rich in polyphenols, bioactive compounds able to prevent cancer, reduce tumorigenesis, and influence critical cancer-related pathways. This research shows the main results obtained in our previous works: 1) the characterization of the polyphenolic content and antioxidant activity of two table grape skin extracts (GSEs), Autumn Royal, and Egnatia; 2) the GSEs effects on Caco2 colon cancer cell; 3) the effects of GSEs on the lipid composition and the fluidity of the cell membrane. These in vitro studies suggested that Autumn Royal and Egnatia contain high levels of polyphenols, possess antiproliferative activity on the Caco2 human colon carcinoma cell line and inhibit cell migration by acting on membrane fatty acids composition. Moreover, these results highlighted that the new grape variety Egnatia is an exciting source of phenolic compounds that could interest the food and pharmaceutical industries.