Research on the Influence of Toosendanin on Endometrial Cancer by Regulating p27kip1 and Its Clinical Significance

Open Access

Issue		BIO Web Conf. Volume 182, 2025 The 3^rd International Conference on Food Science and Bio-medicine (ICFSB 2025)


Article Number		02009
Number of page(s)		6
Section		Biomedical Research and Applications
DOI		https://doi.org/10.1051/bioconf/202518202009
Published online		02 July 2025

Wang Peiyu, Huang Qi, Wang Shaodong, et al. Interpretation of the Key Points of “Global Cancer Statistics 2022” [J]. Chinese Journal of Clinical Thoracic and Cardiovascular Surgery, 2024, 31(07): 933–945. [Google Scholar]
Shen Xiaoyu, Jia Yue, Yang Zhiqin, et al. Research Progress on the Epidemiological Trends and Risk Factors of Endometrial Cancer [J]. South China Journal of Preventive Medicine, 2022, 48(9): 1079–1081, 1086. [Google Scholar]
Zhang Xin, Wang Jiandong. Research Progress on the Epidemiological High-risk Factors Related to Endometrial Cancer [J]. Medical Recapitulate, 2021, 27(15): 2995–2999. [Google Scholar]
Xiao Tingting. A Correlative Study on TCM Syndrome Elements and Risk Factors in Patients with Endometrial Cancer [D]. Guangxi University of Chinese Medicine, 2024. [Google Scholar]
Li Fang, Zhang Guo, Wang Jianliu. Research Progress on the Screening of Endometrial Cancer [J]. Chinese Journal of Clinical Obstetrics and Gynecology, 2025, 26(02): 152–155. [Google Scholar]
Mcdonald M E, Bender D P. Endometrial Cancer: Obesity, Genetics, and Targeted Agents [J]. Obstetrics and Gynecology Clinics of North America, 2019, 46(1): 89–105. [Google Scholar]
P. Russell, B.T. Hennessy, J. Li, M.S. Carey, R.C. Bast, T. Freeman, et al.. Cyclin G1 regulates the outcome of taxane-induced mitotic checkpoint arrest Oncogene, 31 (2012), pp. 2450–2460. [Google Scholar]
C. Wang, Z. Li, M. Fu, T. Bouras, R.G. Pestell. Signa l transduction mediated by cyclin D1: from mitogens to cell proliferation: a molecular target with therapeutic potential Cancer Treat Res, 119 (2004), pp. 217–237. [Google Scholar]
Y. Geng, Q. Yu, W. Whoriskey, F. Dick, K.Y. Tsai, H.L. Ford, et al. Expression of cyclins E1 and E2 during mouse development and in neoplasia Proc Nat Acad Sci U S Am, 98 (2001), pp. 13138–13143. [Google Scholar]
P. Russell, B.T. Hennessy, J. Li, M.S. Carey, R.C. Bast, T. Freeman, et al.. Cyclin G1 regulates the outcome of taxane-induced mitotic checkpoint arrest Oncogene, 31 (2012), pp. 2450–2460. [Google Scholar]
G.A. Gonçalves, p27kip1 as a key regulator of endometriosis, European Journal of Obstetrics & Gynecology and Reproductive Biology, Volume 221, 2018, Pages 1–4, ISSN 0301-2115. [Google Scholar]
Kumari S, Kumar P, Kumar M, Singh S, Narayan G. Expression of p27 and p16 and their clinical significance in gastric cancer. Clin Transl Oncol. 2021 Apr;23(4):856–865. [CrossRef] [PubMed] [Google Scholar]
Bamberger AM, Riethdorf L, Midle LK, et al. Strongly reduced expression of the cell cycle inhibitor p27 in endometrial neoplasia. Virchows-Arch, 1999, 434(5): 423–428. [Google Scholar]
Nycum LR, Smith LM, Farley JH, et al. The role of p27 in endometrial carcinoma [J]. Gynecol Oncol, 2001, 81(2): 242–246. [Google Scholar]
Schmitz MJ, Hendricks DT, Farley J, et al. p27 and cyclin D1 abnormalities in uterine papillary serous carcinoma [J]. Gynecol Oncol, 2000, 77(3): 439–445.1 [Google Scholar]
A. Abargel, I. Avinoach, V. Kravtsov, M. Boaz, M. Glezerman, J. Menczer, Expression of p27 and p53: comparative analysis of uterine carcinosarcoma and endometrial carcinoma, International Journal of Gynecological Cancer, Volume 14, Issue 2, 2004, Pages 354359, ISSN 1048-891X. [Google Scholar]
Pharmacopoeia Commission of the People’s Republic of China. Pharmacopoeia of the People’s Republic of China: Volume I [M]. Beijing: China Medical Science Press, 2020: 156. [Google Scholar]
Wu Qianru. Study on the Triterpenoid Chemical Constituents in Fruit of Melia toosendan Sieb. et Zucc. [J]. Journal of Shanxi Medical University, 2024, 55(01):104–107. [Google Scholar]
Li Haibo, Ma Senju, Shi Danfeng, et al. Research Progress on the Chemical Constituents, Pharmacological Effects and Toxicity of Fruit of Melia toosendan Sieb. et Zucc. [J]. Chinese Traditional and Herbal Drugs, 2020, 18(01):38–43. [Google Scholar]
Wang Siyu, Cui Yuexin, Zhang Jingzhen, et al. Discussion on the Influence of Compatibility of Different Proportions of Fruit of Melia toosendan Sieb. et Zucc. and Radix Glycyrrhizae on the Dissolution of Chemical Constituents and Hepatocyte Toxicity Based on the Entropy Weight Method [J]. Central South Pharmacy, 2020, 18(01):38–43. [Google Scholar]
Zhang Yu, Fan Mengmeng, Zhu Jianguang, et al. Research Progress on the Chemical Constituents, Pharmacology and Toxicology of Fruit of Melia toosendan Sieb. et Zucc. [J]. Chinese Archives of Traditional Chinese Medicine, 2023, 41(12):218–226. [Google Scholar]
Yang Jianyu, Li Yang, Fan Zhuwen, et al. Recent Research Situation of the Genuine Medicinal Material Fruit of Melia toosendan Sieb. et Zucc. [J]. Guangming Journal of Chinese Medicine, 2020, 35(02):294–296.. [Google Scholar]
Zhou Nong, Yang Min, Bai Zhichuan, et al. Determination of Ferulic Acid Content in Fructus Toosendan from Different Sources by HPLC [J]. Chinese Journal of Experimental Traditional Medical Formulae, 2012, 18(3): 84–87. [Google Scholar]
Yan G Y, Li J, Chen S S, et al. New limonoids from the fruits of Melia toosendan and their autophagic activities [J]. Phytochemistry Letters, 2020, 35: 15–22. [Google Scholar]
LI S, LI Y, XU R, et al. New eliacarpin-type (C-seco) and C-ring intact limonoids from the fruits of Melia toosendan [J]. Fitoterapia, 2020, 144: 104605. [Google Scholar]
Zhu Dacheng, Liu Zhenshuai, Wu Huiting, et al. Study on the Mechanism of the Extract of Fructus Toosendan in Inhibiting the Proliferation of Leukemia Cells [J]. Chinese Archives of Traditional Chinese Medicine, 2023, 41(4): 259–261. [Google Scholar]
Zhang Yu, Fan Mengmeng, Zhu Jianguang, et al. Research Progress on the Chemical Constituents, Pharmacology and Toxicology of Fructus Toosendan [J]. Chinese Archives of Traditional Chinese Medicine, 2023, 41(12): 218–226. [Google Scholar]
Kitagawa K, Moriya K, Kaji K, et al. Atorvastatin augments gemcitabine-mediated anticancer effects by inhibiting yes-associated protein in human cholangiocarcinoma cells[J]. International Journal of Molecular Sciences, 2020, 21(20): 7588. [Google Scholar]
Redin E, Garmendia I, Lozano T, et al. SRC family kinase (SFK) inhibitor dasatinib improves the antitumor activity of anti-PD-1 in NSCLC models by inhibiting Treg cell conversion and proliferation[J]. Journal for ImmunoTherapy of Cancer, 2021, 9(3): e001496. [Google Scholar]
Tian Shuang, Zhao Ying, Liu Chao. Effects of YAP1 Targeted Inhibitor CA3 on the Proliferation and Apoptosis of Human Endometrial Carcinoma Cells and Its Molecular Mechanism [J]. Chinese Journal of Modern Applied Pharmacy, 2023, 40(10):1307–1312.. [Google Scholar]
Hsu M, Cocaprados M. Electron microscopic evidence for the circular form of rna in the cytoplasm of eukaryotic cells[J]. Nature, 1979, 280(5720): 339–340. [Google Scholar]
Liu Hui. Study on the Molecular Mechanism of the Regulation of Gastric Cancer Growth by circYAP1 Mediated by Toosendanin [D]. Shanghai Jiao Tong University, 2019. [Google Scholar]

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